Neurotoxicidad causada por contaminantes ambientales y papel de la microbiota intestinal y la suplementación con selenio [Plan de Gestión de Datos]
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Vélez-Pérez, R. de F., Arias-Borrego, A., Velasco, I., Soldevila, B., & García-Barrera, T. (2025). Liquid chromatography (ion mobility) coupled to organic and inorganic mass spectrometry for determination of eight thyroid hormones in human milk with enantiomeric separation of thyroxine. Food Chemistry, 492. https://doi.org/10.1016/J.FOODCHEM.2025.145542
Huertas-Abril, P. V., Prieto-Álamo, M.-J., Jurado, J., Pérez, J., Molina-Hernández, V., García-Barrera, T., & Abril, N. (2024). Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet. In Food and Chemical Toxicology (Vol. 191, p. 114845). Elsevier BV. https://doi.org/10.1016/j.fct.2024.114845
Rodríguez-Moro, G., Cabrera-Rubio, R., Selma-Royo, M., Gómez-Morlote, J. A., Collado, M. C., Abril, N., & García-Barrera, T. (2025). Modulation of the gut microbiota and the microbial-produced gut metabolites by diclofenac exposure and selenium supplementation. In Environmental Science and Pollution Research. Springer Science and Business Media LLC. https://doi.org/10.1007/s11356-025-36233-6
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Ramírez-Acosta, S., Huertas-Abril, P. V., Selma-Royo, M., Prieto-Álamo, M. J., Collado, M. C., Abril, N., & García-Barrera, T. (2023). The role of selenium in shaping mice brain metabolome and selenoproteome through the gut-brain axis by combining metabolomics, metallomics, gene expression, and amplicon sequencing. In The Journal of Nutritional Biochemistry (Vol. 117, p. 109323). Elsevier BV. https://doi.org/10.1016/j.jnutbio.2023.109323
Villegas-Álvarez, M. C., Arias-Borrego, A., Velasco, I., & García-Barrera, T. (2023). Ultrasound-assisted three-phase hollow fiber microextraction-based method for untargeted metabolomics. Microchemical Journal, 195, 109473. https://doi.org/10.1016/j.microc.2023.109473
Arias‐Borrego, A., Callejón‐Leblic, B., Collado, M. C., Abril, N., & García‐Barrera, T. (2023). Omics insights into the responses to dietary selenium. In Proteomics (Vol. 23, Issues 23–24). Wiley. https://doi.org/10.1002/pmic.202300052
Cánovas, C. R., Quispe, D., Macías, F., Callejón-Leblic, B., Arias-Borrego, A., García-Barrera, T., & Nieto, J. M. (2023). Potential release and bioaccessibility of metal/loids from mine wastes deposited in historical abandoned sulfide mines. In Environmental Pollution (Vol. 316, p. 120629). Elsevier BV. https://doi.org/10.1016/j.envpol.2022.120629
Trombini, C., Rodríguez-Moro, G., Ramírez Acosta, S., Gómez Ariza, J. L., Blasco, J., & García-Barrera, T. (2022). Single and joint effects of cadmium and selenium on bioaccumulation, oxidative stress and metabolomic responses in the clam Scrobicularia plana. In Chemosphere (Vol. 308, p. 136474). Elsevier BV. https://doi.org/10.1016/j.chemosphere.2022.136474
Guimarães, B. O., Villarreal-Toribio, B., García-Barrera, T., Arias-Borrego, A., Gremmen, P., Wijffels, R. H., Barbosa, M. J., & D’Adamo, S. (2022). Effect of sulphur on selenium accumulation and speciation in Nannochloropsis oceanica. In Journal of Functional Foods (Vol. 96, p. 105215). Elsevier BV. https://doi.org/10.1016/j.jff.2022.105215
C. Parra-Martínez, M. Selma-Royo, B. Callejón-Leblic, M.C. Collado, N. Abril, T. García-Barrera, Mice brain metabolomics after the exposure to a “chemical cocktail” and selenium supplementation through the gut-brain axis, Journal of Hazardous Materials, Volume 438, 2022, 129443, ISSN 0304-3894, https://doi.org/10.1016/j.jhazmat.2022.129443
Ramírez-Acosta, S., Selma-Royo, M., Collado, M. C., Navarro-Roldán, F., Abril, N., & García-Barrera, T. (2022). Selenium supplementation influences mice testicular selenoproteins driven by gut microbiota. In Scientific Reports (Vol. 12, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-022-08121-3
G. Rodríguez-Moro, C. Román-Hidalgo, S. Ramírez-Acosta, N. Aranda-Merino, J.L. Gómez-Ariza, N. Abril, M.A. Bello-López, R. Fernández-Torres, T. García-Barrera, Targeted and untargeted metabolomic analysis of Procambarus clarkii exposed to a “chemical cocktail” of heavy metals and diclofenac, Chemosphere, Volume 293, 2022, 133410, ISSN 0045-6535, https://doi.org/10.1016/j.chemosphere.2021.133410
Arias-Borrego, A., Selma-Royo, M., Collado, M. C., Abril, N., & García-Barrera, T. (2022). Impact of “chemical cocktails” exposure in shaping mice gut microbiota and the role of selenium supplementation combining metallomics, metabolomics, and metataxonomics. Journal of Hazardous Materials, 438, 129444. https://doi.org/10.1016/j.jhazmat.2022.129444
Callejón-Leblic, B., Selma-Royo, M., Collado, M. C., Gómez-Ariza, J. L., Abril, N., & García-Barrera, T. (2021). Untargeted Gut Metabolomics to Delve the Interplay between Selenium Supplementation and Gut Microbiota. In Journal of Proteome Research. American Chemical Society (ACS). https://doi.org/10.1021/acs.jproteome.1c00411
Ramírez-Acosta, S., Uhlírová, R., Navarro, F., Gómez-Ariza, J. L., & García-Barrera, T. (2022). Antagonistic Interaction of Selenium and Cadmium in Human Hepatic Cells Through Selenoproteins. In Frontiers in Chemistry (Vol. 10). Frontiers Media SA. https://doi.org/10.3389/fchem.2022.891933
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Abstract
El subproyecto UHU generará datos experimentales procedentes de ensayos de exposición controlada en modelos murinos (Mus musculus) a contaminantes ambientales (arsénico, manganeso, mercurio, aluminio) y a compuestos farmacológicamente activos, con o sin suplementación con selenio y con microbiota intestinal normal o depletada. Los datos incluirán resultados analíticos de técnicas ómicas como metabolómica, metataxonómica, metaproteómica, metatranscriptómica y metalómica, así como datos de comportamiento, histología, bioquímica y parámetros de salud reproductiva.
Los datos se crearán en diferentes formatos, incluyendo:
- Tablas (xlsx, csv) con resultados analíticos cuantitativos;
- Imágenes (tif, png) procedentes de histología y electroforesis;
- Documentos de texto (docx, pdf) con protocolos experimentales y resultados resumidos;
- Archivos brutos de equipos instrumentales (HPLC-ICP-MS, QTOF, GC-MS, Illumina MiSeq, etc.).
El propósito de la generación de estos datos es respaldar los objetivos del proyecto, que buscan comprender los mecanismos de neurotoxicidad inducidos por contaminantes ambientales, el papel modulador de la microbiota intestinal y los efectos protectores de la suplementación con selenio. Los datos serán utilizados para publicaciones científicas, conferencias y posibles proyectos futuros.
El tamaño total estimado de los datos generados será de aproximadamente 100 GB, considerando datos instrumentales, imágenes y resultados derivados. El almacenamiento se realizará en los servidores institucionales de la Universidad de Huelva con copias de seguridad periódicas.
Los datos son originales, generados en el marco del proyecto. No se reutilizan datasets externos salvo bases de referencia públicas (por ejemplo, NCBI o KEGG) para identificación y anotación de proteínas y metabolitos. La utilidad potencial de estos datos fuera del proyecto incluye su empleo por otros grupos de investigación en toxicología ambiental, microbiota, metabolómica o biología del selenio. Asimismo, pueden contribuir a la normalización de metodologías analíticas en estudios de interacción microbiota-contaminantes.
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