@article{10272/27653,
year = {2022},
url = {https://hdl.handle.net/10272/27653},
abstract = {The [Ru(bpy)2(Nor)2]2+ complex (Nor = nornicotine) is an efficient catalyst for the aldol reaction of acetone with activated benzaldehydes in a buffered aqueous solution. The metal plays the role of an activator for the nornicotine organocatalyst ligands. The resulting catalytic activity is potentiated by a factor of about 4.5 as compared to free nornicotine. Similar rate enhancements can be achieved by using Zn(II) cations as the activator. The observations are rationalized with the reduced basicity of the pyrrolidine N in nornicotine due to the enhanced electron withdrawal of the metal-complexed pyridyl moiety.},
organization = {The authors acknowledge the funding by the Spanish Ministry of Science, Innovation, and Universities (grant CTQ201789832-P and PID2020-119992GB-I00 for U.P.) and the University of Huelva (grant UHU-9-542-2019 for J.F.A.).},
publisher = {American Chemical Society},
title = {Metal-Mediated Organocatalysis in Water: Serendipitous Discovery of Aldol Condensation Catalyzed by the [Ru(bpy)2(nornicotine)2]2+ Complex},
doi = {10.1021/acs.joc.2c00472},
doi = {1520-6904 (electrónico)},
author = {Guzmán Ríos, David and Romero, Miguel Ángel and González Delgado, José Antonio and Fernández Arteaga, Jesús and Pischel, Uwe},
}