RT Journal Article
T1 Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOP REV Study)
A1 Rodríguez Ortiz, M. Encarnación
A1 Gómez Delgado, Francisco
A1 Arenas de Larriva, Antonio P.
A1 Canalejo Raya, Antonio
AB This study aimed to ascertain whether there is an independent association between serum magnesium(Mg) and the Carotid Intima-Media Thickness (IMT-CC), a well-accepted atherosclerotic-biomarkersurrogate of cardiovascular disease (CVD), in a population with high cardiovascular risk. Serum Mgand traditional atherosclerotic risk factors were recorded in 939 patients (mean age, 59.6 ± 0.3 years,83.2% men) with coronary heart disease (CHD) enrolled in the CORDIOPREV trial. Serum Mg stronglyassociated with IMT-CC. Before adjusting for potential confounding factors, IMT-CC decreased by0.111 ± 0.011 mm per mg/dl increase in serum Mg (p < 0.001). After adjustment, the effect of Mg didnot appear mediated through factors related to glucose metabolism, the lipid profile or the mineralmetabolism and renal function. Multivariate models showed the lower Mg levels (quartile 1) as a strongindependent factor contributing to IMT-CC along with age, sex, SBP, HDL-C, and diuretic use. Logisticregression analysis confirmed the predictive ability of serum Mg to differentiate patients at higheratherosclerotic risk as defined by an IMT-CC ≥ 1.0 mm, yielding a OR for the lower quartile of 10.623(95%CI 2.311–48.845; P = 0.002) and a ROC-derived cutoff of 1.61 mg/dl. Therefore, our findings outlinelow serum magnesium as a possible independent risk factor for carotid atherosclerosis.
PB Nature Research
SN 2045-2322
YR 2019
FD 2019-05
LK http://hdl.handle.net/10272/16494
UL http://hdl.handle.net/10272/16494
LA eng
NO Rodríguez Ortiz, M. E., Gómez Delgado, F., Arenas de Larriva, A. P., ... Canalejo Raya, A.,  (2019). Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOPREV Study). Scientific Reports, 9(1). DOI: https://doi.org/10.1038/s41598-019-44322-z
NO We would like to thank the EASP (Escuela Andaluza de Salud Publica), Granada, Spain, who performed the randomization process for this study. The CORDIOPREV study is supported by Fundacion Patrimonio Comunal Olivarero. CITOLIVA and CEAS, Consejeria de Economia, Innovacion y Ciencia (CVI-7450); Ministerio de Economia (AGL2015-67896-P, PIE14/00005, PIE14/00031); Instituto de Salud Carlos III (FIS 14/00872; FIS 17/01024), co-funded with FEDER (European Regional Development Fund). Y. A. is supported by Nicolas Monardes Programme, Consejeria de Salud-SAS. CIBEROBN is an initiative of Instituto de Salud Carlos III.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026