RT Journal Article
T1 Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging
A1 López González, Elga
A1 García Jiménez, Rocío
A1 Rodríguez Jiménez, Alberto
A1 Rojas Luna, José Antonio
A1 Daza Manzano, Cinta
A1 Gómez Salgado, Juan
A1 Álvarez López, Rosa María
AB Objective: To evaluate whether the introduction of tumor volume as new parameter in the MRI assessment could improve both concordance between preoperative and postoperative staging, and the identification of histological findings.Methods: A retrospective observational study with 127 patients with endometrial cancer (EC) identified between 2016 and 2021 at the Juan Ramon Jimenez University Hospital, Huelva (Spain) was carried out. Tumor volume was measured in three ways. Analyses of Receiver Operating Characteristic (ROC) curve and the area under the curve (AUC) were performed.Results: Although preoperative MRI had an 89.6% and 66.7% sensitivity for the detection of deep mucosal invasion and cervical stroma infiltration, preoperative assessment had an intraclass correlation coefficient of 0.517, underestimating tumor final stage in 12.6% of cases, with a poor agreement between preoperative MRI and postoperative staging (κ=0.082) and low sensitivity (14.3%) for serosa infiltration. The cut-off values for all three volume parameters had good/excellent AUC (0.73-0.85), with high sensitivity (70-83%) and specificity (64-84%) values for all histopathological variables. Excellent/good agreement was found all volume parameters for the identification of deep myometrial invasion (0.71), cervical stroma infiltration (0.80), serosa infiltration (0.81), and lymph node metastases (0.81).Conclusion: Tumor volume measurements have good predictive capacity to detect histopathological findings that affect final tumor staging and might play a crucial role in the preoperative assessment of patients with endometrial cancer in the future.
PB Frontiers Media
SN 2234-943X (electrónico)
YR 2023
FD 2023-08
LK https://hdl.handle.net/10272/23917
UL https://hdl.handle.net/10272/23917
LA eng
NO López-González, E., García-Jiménez, R., Rodríguez-Jiménez, A., Rojas-Luna, J. A., Daza-Manzano, C., Gómez-Salgado, J., & Álvarez, R. M. (2023). Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging. In Frontiers in Oncology (Vol. 13). Frontiers Media SA. https://doi.org/10.3389/fonc.2023.1219818
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026