RT Journal Article
T1 Diversion Colitis: Macro and Microscopic Findings after Probiotics Stimulation
A1 Rodríguez Padilla, Ángela
A1 Morales Martín, Germán
A1 Pérez Quintero, Rocío
A1 Gómez Salgado, Juan
A1 Rada Morgades, Ricardo
A1 Ruiz Frutos, Carlos
AB The use of a loop ileostomy as the defunctioning procedure of choice to protect a distalcolonic anastomosis causes histological and endoscopic changes in the intestinal mucosal architecture,which have been related to chronic inflammation and changes in the microflora that consequentlyimpact the intestinal structure and function following fecal stream diversion. The aim of thisstudy was to evaluate the histological and endoscopic changes on the colonic mucosa in patientswith diversion colitis after stimulation of the efferent loop with probiotics prior to closure of theprotective ileostomy. A prospective, randomized, double-blind, controlled study was designed.All patients who underwent surgery for colorectal carcinoma with protective ileostomy betweenJanuary 2017 and December 2018 were included. These patients were pending reconstructive surgeryand were diagnosed with endoscopic and histological diversion colitis. Divided into two groups,a group stimulated with probiotics (SG) and a control group (CG). 34 cases and 35 controls wereincluded in the study. Histological and endoscopic changes were evaluated after stimulation, afterrestorative surgery and during the short-term follow-up after surgery. A decrease in endoscopicpathological findings (mucosal friability, mucous erosions, polyps, edema, erythema and stenosis) andin histological findings (follicular hyperplasia, eosinophils, cryptic abscesses, lymphocyte infiltration,plasma cell infiltration and architecture distortion) was observed in SG. These results were statisticallysignificant with a p < 0.001. The stimulation of the efferent loop of the ileostomy in patients withdiversion colitis produced a decrease of the endoscopic and histological severity of colitis in the shortterm.
PB MDPI
SN 2079-7737
YR 2021
FD 2021-04
LK http://hdl.handle.net/10272/19786
UL http://hdl.handle.net/10272/19786
LA eng
NO Rodríguez Padilla, Á., Morales Martín, G., Pérez Quintero, R., Gómez Salgado, J., Rada Morgades, R., & Ruiz Frutos, C. (2021). Diversion Colitis: Macro and Microscopic Findings after Probiotics Stimulation. Biology, 10(4), 303. DOI: https://doi.org/10.3390/biology10040303
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026