RT Journal Article
T1 Omics insights into the responses to dietary selenium
A1 Arias Borrego, Ana
A1 Callejón Leblic, María Belén
A1 Collado, Maria Carmen
A1 Abril, Nieves
A1 García Barrera, Tamara
AB Selenium is a well-known health-relevant element related with cancer chemoprevention,neuroprotective roles, beneficial in diabetes, and in several infectious diseases,among others. It is naturally present in some foods, but deficiency in people led tothe production of nutraceuticals, supplements, and functional food enriched in thiselement. There is a U-shaped link between selenium levels and health and a narrowrange between toxic and essential levels, and thus, supplementation should be performedcarefully. Omics methodologies have become valuable approaches to delveinto the responses of dietary selenium in mammals that allowed a deeper knowledgeabout the metabolism of this element as well as its biological role. In this review,we discuss omics approaches from the workflows to their applications that has beenpreviously used to deep insight into the metabolism of dietary selenium. There is a specialfocus on selenoproteins, metabolomics responses in blood and tissues (e.g., brain,reproductive organs, etc.) as well as the impact on gut microbiota and its metabolitesprofile. Thus, we mainly reviewed heteroatom-tagged proteomics, metallomics,metabolomics, and metataxonomics, usually combined with transcriptomics, genomics,and other molecular methods.
PB Wiley
SN 1615-9853
SN 1615-9861 (electrónico)
YR 2023
FD 2023
LK https://hdl.handle.net/10272/23273
UL https://hdl.handle.net/10272/23273
LA eng
NO Arias‐Borrego, A., Callejón‐Leblic, B., Collado, M. C., Abril, N., & García‐Barrera, T. (2023). Omics insights into the responses to dietary selenium. In Proteomics (Vol. 23, Issues 23–24). Wiley. https://doi.org/10.1002/pmic.202300052
NO Spanish Ministry of Economy and Competitiveness (MINECO), Grant/Award Numbers: UHU-202009, PY20_00366; FEDER Andalusian Operative Program 2014–2020 (Ministry of Economy, Knowledge, Business and Universities, Regional Government of Andalusia, Spain); FEDER (European Community), Grant/Award Number: UNHU13-1E-1611; Ministerio de Ciencia e Innovación, Grant/Award Number: PID2021-123073NB-C21; Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía, Grant/Award Numbers: PY20_00366, UHU-202009; Spanish Government MCIN/AE-Center of Excellence Accreditation SeveroOchoa, Grant/Award Number: CEX2021-001189-S/MCIN/AEI/10.13039/501100011033; Spanish Ministry of Science and Innovation (MCIN), Grant/Award Number: PID2022-139475OB-I00
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026