RT Journal Article
T1 The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
A1 Navarro Roldán, Francisco Juan
A1 Toimil, Alberto
A1 Ramírez, Sara
A1 Montero, Yina
AB Biomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxiceffects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals.Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantlyincreased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of C. onubensis powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats againstcardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol(26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin.The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however,C. onubensis powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmiticand arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the dietof rats.
PB Springer
SN 1573-5176
YR 2020
FD 2020-10
LK http://hdl.handle.net/10272/18995
UL http://hdl.handle.net/10272/18995
LA eng
NO Navarro Domínguez, F., Toimil, A., Ramírez, S. ... Montero, Y. (2020). The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets. Journal of Applied Phycology. DOI: https://doi.org/10.1007/s10811-020-02280-4
DS Repositorio Institucional de la Universidad de Huelva
RD 14 jul 2026