RT Journal Article
T1 Glucose Levels as a Mediator of the Detrimental E ect of Abdominal Obesity on Relative Handgrip Strength in Older Adults
A1 Pérez Sousa, Miguel Ángel
A1 Pozo Cruz, Jesús del
A1 Cano Gutierrez, Carlos Alberto
A1 Ramírez Vélez, Robinson
AB Excess central adiposity accelerates the decline of muscle strength in older people.Additionally, hyperglycemia, independent of associated comorbidities, is related to the loss of musclemass and strength, and contributes to functional impairment in older adults. We studied the mediatione ect of glucose levels, in the relationship between abdominal obesity and relative handgrip strength(HGS). A total of 1571 participants (60.0% women, mean age 69.1   7.0 years) from 86 municipalitieswere selected following a multistage area probability sampling design. Measurements includeddemographic and anthropometric/adiposity markers (weight, height, body mass index, and waistcircumference). HGS was measured using a digital dynamometer for three sets and the meanvalue was recorded. The values were normalized to body weight (relative HGS). Fasting glucosewas analyzed by enzymatic colorimetric methods. Mediation analyses were performed to identifyassociations between the independent variable (abdominal obesity) and outcomes (relative HGS),as well as to determine whether fasting glucose levels mediated the relationship between excessadiposity and relative HGS. A total of 1239 (78.8%) had abdominal obesity. Abdominal obesity had anegative e ect on fasting glucose (  ß = 9.04, 95% CI = 5.87 to 12.21); while fasting glucose to relativeHGS was inversely related (  ß = -0.003, 95% CI = -0.005 to -0.001), p < 0.001. The direct e ectof abdominal obesity on relative HGS was statistically significant (  ß = -0.069, 95% CI = -0.082 to-0.057), p < 0.001. Lastly, fasting glucose levels mediates the detrimental e ect of abdominal obesityon relative HGS (indirect effect   = -0.002, 95% CI = -0.004 to -0.001), p < 0.001. Our results suggestthat the glucose level could worsen the association between abdominal obesity status and lowerHGS. Thus, it is plausible to consider fasting glucose levels when assessing older adults with excessadiposity and/or suspected loss of muscle mass.
PB MDPI
SN 2077-0383
YR 2020
FD 2020-07
LK http://hdl.handle.net/10272/18800
UL http://hdl.handle.net/10272/18800
LA eng
NO Pérez Sousa, M. Á., del Pozo Cruz, J., Cano Gutiérrez, C. A. ... Ramírez Vélez, R. (2020). Glucose Levels as a Mediator of the Detrimental Effect of Abdominal Obesity on Relative Handgrip Strength in Older Adults. Journal of Clinical Medicine, 9(8), 2323. DOI: https://doi.org/10.3390/jcm9082323
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026