RT Journal Article
T1 Population-based multicase-control study in common tumors in Spain (MCC-Spain) : rationale and study design
A1 Castaño Vinyals, Gemma
A1 Alguacil Ojeda, Juan
A1 Kogevinas, Manolis
AB Introduction: We present the protocol of a large population-based case-control study of 5 common tumorsin Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primarycare centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer,1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chroniclymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age,sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) andfrom 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographicfactors, environmental exposures, occupation, medication, lifestyle, and personal and familymedical history. In addition, participants completed a self-administered food-frequency questionnaireand telephone interviews. Blood samples were collected from 76% of participants while saliva sampleswere collected in CLL cases and participants refusing blood extractions. Clinical information was recordedfor cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals.Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multipleanalyses are planned to assess the association of environmental, personal and genetic risk factorsfor each tumor and to identify pleiotropic effects.Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology& Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancersand will promote cancer research and prevention in Spain.
PB Elsevier
SN 0213-9111
SN 1578-1283 (electrónico)
YR 2014
FD 2014
LK http://hdl.handle.net/10272/12087
UL http://hdl.handle.net/10272/12087
LA eng
NO Castaño Vinyals, G., Alguacil Ojeda, J., Kogevinas, M.: "Population-based multicase-control study in common tumors in Spain (MCC-Spain) : rationale and study design". Gaceta Sanitaria. Vol. 29, n. 4, págs. 308-315, (2014). DOI: 10.1016/j.gaceta.2014.12.003
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026