RT Journal Article
T1 Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)
A1 Obón Santacana, Mireia
A1 Alguacil Ojeda, Juan
A1 Amiano, Pilar
AB Inflammation and antioxidant capacity have been associated with colorectal and breastcancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymaticantioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in thepopulation-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancerand 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score andNEAC were derived using data from a semi-quantitative validated food frequency questionnaire.Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidenceintervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII wasassociated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60–2.32;p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronouncedincreased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest,95%CI:0.99–1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant valueswere associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26–1.74;p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet isassociated with increased colorectal cancer risk while findings for breast cancer were less consistent.
PB MDPI
SN 2072-6643
YR 2019
FD 2019
LK http://hdl.handle.net/10272/16612
UL http://hdl.handle.net/10272/16612
LA eng
NO Obón-Santacana, Alguacil Ojeda, J., Amiano... y otros (2019). Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients, 11(6), 1406. https://doi.org/10.3390/nu11061406
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026