RT Journal Article
T1 Mechanistic Insights into Alzheimer’s Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways
A1 González Domínguez, Raúl
A1 González Domínguez, Álvaro
A1 Sayago Gómez, Ana
A1 González Sanz, Juan Diego
A1 Lechuga Sancho, Alfonso María
A1 Fernández Recamales, María Ángeles
AB Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer’s disease. This review article provides a comprehensive revision of the literature published on the use of mass spectrometry-based metabolomics platforms for approaching the central metabolome in Alzheimer’s disease research, including direct mass spectrometry, gas chromatography-mass spectrometry, hydrophilic interaction liquid chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry. Overall, mounting evidence points to profound disturbances that affect a multitude of central metabolic pathways, such as the energy-related metabolism, the urea cycle, the homeostasis of amino acids, fatty acids and nucleotides, neurotransmission, and others.
PB BIOMEDICINES
YR 2021
FD 2021
LK http://hdl.handle.net/10272/19772
UL http://hdl.handle.net/10272/19772
LA eng
NO González-Domínguez, R.; González-Domínguez, Á.; Sayago, A.; González-Sanz, J.D.; Lechuga-Sancho, A.M.; Fernández-Recamales, Á. Mechanistic Insights into Alzheimer’s Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways. Biomedicines 2021, 9, 298. https://doi.org/10.3390/ biomedicines9030298
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026