RT Journal Article
T1 Association of occupational heat exposure and colorectal cancer in the MCC-Spain study
A1 Hinchliffe, Alice
A1 Alguacil Ojeda, Juan
A1 Turner, Michelle C.
AB Objective Heat exposure and heat stress/strain is a concern for many workers. There is increasing interest inpotential chronic health effects of occupational heat exposure, including cancer risk. We examined potentialassociations of occupational heat exposure and colorectal cancer (CRC) risk in a large Spanish multi-case–controlstudy.Methods We analyzed data on 1198 histologically confirmed CRC cases and 2690 frequency-matched controls.The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to the lifetime occupationsof participants. Three exposure indices were assessed: ever versus never exposed, cumulative exposure andduration (years). We estimated odds ratios (OR) and 95% confidence intervals (CI) using unconditional logisticregression adjusting for potential confounders.Results Overall, there was no association of ever, compared with never, occupational heat exposure and CRC(OR 1.09, 95% CI 0.92–1.29). There were also no associations observed according to categories of cumulativeexposure or duration, and there was no evidence for a trend. There was no clear association of ever occupationalheat exposure and CRC in analysis conducted among either men or women when analyzed separately. Positiveassociations were observed among women in the highest categories of cumulative exposure (OR 1.81, 95% CI1.09–3.03) and duration (OR 2.89, 95% CI 1.50–5.59) as well as some evidence for a trend (P<0.05).Conclusion Overall, this study provides no clear evidence for an association between occupational heat exposureand CRC.
PB Nordic Association of Occupational Safety and Health (NOROSH)
SN 0355-3140
SN 1795-990X (electrónico)
YR 2023
FD 2023
LK https://hdl.handle.net/10272/22409
UL https://hdl.handle.net/10272/22409
LA eng
NO Hinchliffe, A., Kogevinas, M., Molina, A. J., Moreno, V., Aragonés, N., Castaño-Vinyals, G., Jiménez Moleón, J. J., Gómez Acebo, I., Ederra, M., Amiano, P., Molina-Barceló, A., Fernandez-Tardon, G., Alguacil, J., Chirlaque, M.-D., Hernández-Segura, N., Pérez-Gómez, B., Pollan, M., & Turner, M. C. (2023). Association of occupational heat exposure and colorectal cancer in the MCC-Spain study. In Scandinavian Journal of Work, Environment &amp; Health (Vol. 49, Issue 3, pp. 211–221). Scandinavian Journal of Work, Environment and Health. https://doi.org/10.5271/sjweh.4082
NO The study was partially funded by the "Accion Transversal del Cancer", approved by the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265), the Fundación Marqués de Valdecilla (API 10/09), the Junta de Castilla y León (LE22A10-2), the Consejería de Salud of the Junta de Andalucía (2009-S0143), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa (2010ACUP 00310), the Regional governmentof the Basque Country, the Consejería de Sanidad de la Región de Murcia, the European Commission grantsFOOD-CT-2006–036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, the Catalan Government DURSI grant 2014SGR647, the support of the Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia (2017SGR1085), the Fundación Caja de Ahorros de Asturias and by the University of Oviedo. MCT is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and co-funded by theEuropean Social Fund. We acknowledge support fromthe Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. Statistical assistance provided by Ana Espinosa Morano was greatly appreciated.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026