@article{10272/23701,
year = {2024},
month = {4},
url = {https://hdl.handle.net/10272/23701},
abstract = {Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC.
Methods: We pooled data from 11 population or hospital-based case–control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietary fibers and other dietary factors was collected using food frequency questionnaires. We calculated the odds ratios (OR) and 95% confidence intervals (CI) of the association between dietary fiber intake and GC by using a multivariable logistic regression model adjusted for study site, sex, age, caloric intake, smoking, fruit and vegetable intake, and socioeconomic status. We conducted stratified analyses by these factors, as well as GC anatomical site and histological type.
Results: The OR of GC for an increase of one quartile of fiber intake was 0.91 (95% CI: 0.85, 0.97), that for the highest compared to the lowest quartile of dietary fiber intake was 0.72 (95% CI: 0.59, 0.88). Results were similar irrespective of anatomical site and histological type.
Conclusion: Our analysis supports the hypothesis that dietary fiber intake may exert a protective effect on GC.},
organization = {Open access funding provided by Alma Mater Studiorum - Università di Bologna within the CRUI-CARE Agreement. This study was funded by the Associazione Italiana per la Ricerca sul Cancro (Project number 21378, Investigator Grant). NL and SM are funded under the Unidade de Investigação em Epidemiologia - Instituto de Saúde Pública da Universidade do Porto (EPIUnit; UIDB/04750/2020) financed by national funds from the Foundation for Science and Technology – FCT (Portuguese Ministry of Science, Technology and Higher Education). SM also received funding under the scope
of the project "NEON-PC – Neuro-oncological complications of
prostate cancer: longitudinal study of cognitive decline" (POCI-01-0145-FEDER-032358; Ref. PTDC/SAU-EPI/32358/2017) funded by FEDER through the Operational Program Competitiveness and Internationalization, and national funding from FCT, and the EPIunit – Junior Research – Prog Financing (UIDP/04750/2020). The authors
thank the European Cancer Prevention Organization for providing support for the project meetings. We also thank all MCC-Spain study collaborators (CIBERESP, ISCIII, ISGlobal, ICO, University of Huelva, University of Oviedo, University of Cantabria, University of Leòn, ibs. Granada, Instituto Salud Pública de Navarra, FISABIO, Murcia Regional Health Authority and cols).},
publisher = {Springer},
title = {The association between dietary fiber intake and gastric cancer: a pooled analysis of 11 case–control studies},
doi = {10.1007/s00394-024-03388-w},
author = {Collatuzzo, Giulia and Santos Sánchez, Vanessa and Boffetta, Paolo},
}