RT Journal Article
T1 Measuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophiles
A1 Olmos Verge, Andrea
A1 Gava, Riccardo
A1 Caballero Bevia, Ana
A1 Pérez Romero, Pedro José
AB We report quantitative measurements of the relative reactivities of a series of C-H bonds of gaseous or liquid CnH2n+2 alkanes (n = 1-8, 29 different C-H bonds) towards insitu generated electrophiles (copper, silver, and rhodium carbenes), with methane as the reference. This strategy surpasses the drawback of previous model reactions of alkanes with strong electrophiles suffering from C-C cleavage processes, which precluded direct comparison of the relative reactivities of alkane C-H bonds.
PB Wiley
SN 1433-7851
SN 1521-3773 electrónico
YR 2018
FD 2018
LK http://hdl.handle.net/10272/15974
UL http://hdl.handle.net/10272/15974
LA eng
NO Olmos, A., Gava, R., Noverges, B., Bellezza, D., Jacob, K., Besora, M., Caballero Bevia, A., Pérez Romero, P. J. (2018). Measuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophiles. Angewandte Chemie International Edition, 57(42), 13848-13852. https://doi.org/10.1002/anie.201807448
NO We thank MINECO for support with Grants CTQ2014-52769-C03-01, CTQ2014-52769-C03-02, CTQ2017-82893-C2-1-R, CTQ2014-62234-EXP, CTQ2015-73693-JIN, CTQ2017-87792-R, Severo Ochoa Excellence Accreditation 2014-2018 (SEV-2013-0319), and Red Intecat (CTQ2016-81923-REDC). Junta de Andalucia is also acknowledged for Grant P12-FQM-1765. R.G. and A.O. thank MINECO for FPI and Juan delaCierva fellowships, respectively. B.N. thanks MEC for a FPU fellowship. The CNRS is thanked for support.
DS Repositorio Institucional de la Universidad de Huelva
RD 13 jul 2026