RT Journal Article
T1 Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study
A1 Peralta, Gabriela P.
A1 Sánchez Ramos, José Luis
A1 García Aymerich, Judith
AB Previous studies have reported anassociation between weight increase and excess lungfunction decline in young adults followed for shortperiods. We aimed to estimate lung function trajectoriesduring adulthood from 20-yearweight change profilesusing data from the population-basedEuropeanCommunity Respiratory Health Survey (ECRHS). We included 3673 participants recruitedat age 20–44 years with repeated measurements ofweight and lung function (forced vital capacity (FVC),forced expiratory volume in 1 s (FEV1)) in three studywaves (1991–93, 1999–2003, 2010–14) until they were39–67 years of age. We classified subjects into weightchange profiles according to baseline body mass index(BMI) categories and weight change over 20 years. Weestimated trajectories of lung function over time as afunction of weight change profiles using population-averagedgeneralised estimating equations. In individuals with normal BMI, overweightand obesity at baseline, moderate (0.25–1 kg/year) andhigh weight gain (>1 kg/year) during follow-upwereassociated with accelerated FVC and FEV1 declines.Compared with participants with baseline normal BMIand stable weight (±0.25 kg/year), obese individualswith high weight gain during follow-uphad −1011 mL(95% CI −1.259 to −763) lower estimated FVC at65 years despite similar estimated FVC levels at 25years. Obese individuals at baseline who lost weight(<−0.25 kg/year) exhibited an attenuation of FVC andFEV1 declines. We found no association between weightchange profiles and FEV1/FVC decline. Moderate and high weight gain over20 years was associated with accelerated lung functiondecline, while weight loss was related to its attenuation.Control of weight gain is important for maintaining goodlung function in adult life
PB BMJ
SN 0040-6376
SN 1468-3296 (electrónico)
YR 2020
FD 2020
LK https://hdl.handle.net/10272/23982
UL https://hdl.handle.net/10272/23982
LA eng
NO Peralta, G. P., Marcon, A., Carsin, A.-E., Abramson, M. J., Accordini, S., Amaral, A. F., Antó, J. M., Bowatte, G., Burney, P., Corsico, A., Demoly, P., Dharmage, S., Forsberg, B., Fuertes, E., Garcia-Larsen, V., Gíslason, T., Gullón, J.-A., Heinrich, J., Holm, M., … Garcia-Aymerich, J. (2020). Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study. In Thorax (Vol. 75, Issue 4, pp. 313–320). BMJ. https://doi.org/10.1136/thoraxjnl-2019-213880
NO The present analyses are part of the Ageing Lungs in European Cohorts(ALEC) Study ( www. alecstudy. org), which has received funding from the EuropeanUnion’s Horizon 2020 research and innovation programme under grant agreementNo. 633212. The local investigators and funding agencies for the EuropeanCommunity Respiratory Health Survey are reported in the online supplement.ISGlobal is a member of the CERCA Programme, Generalitat de Cataluña
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026