RT Journal Article
T1 Toenail concentrations of trace elements and occupational history in pancreatic cancer
A1 Camargo, Judit
A1 Pumarega, José A.
A1 Alguacil Ojeda, Juan
A1 Sanz Gallén, Pere
AB Background: Some occupations potentially entailing exposure to cadmium, arsenic, lead, selenium, nickel, andchromium have been associated with an increased risk of exocrine pancreatic cancer (EPC), but no studies haveassessed whether body concentrations of such compounds differed among subjects occupationally exposed andunexposed. No studies which found that exposure to such metals increased the risk of EPC assessed whether pastoccupations were the source of exposure.Objective: The aim was to analyse the relationship between toenail concentrations of trace elements and occupationalhistory in EPC patients.Methods: The study included 114 EPC cases personally interviewed on occupational history and lifestyle factors.Occupations were coded according to the International Standard Classification of Occupations 1988. Selectedoccupational exposures were assessed by two industrial hygienists and with the Finnish job-exposure matrix(Finjem). Concentrations of 12 trace elements were determined in toenail samples by inductively coupled plasmamass spectrometry. Adjusted geometric means (aGMs) and 95% confidence intervals (95% CI) were calculated.Results: Patients occupationally exposed to aromatic hydrocarbon solvents (AHs) had higher concentrations ofcadmium, manganese, lead, iron and vanadium. The aGM of cadmium concentrations for cases exposed to anypesticide was 0.056 μg/g [95% CI: 0.029–0.108], and, for unexposed cases, 0.023 μg/g [0.017–0.031]. Patientsoccupationally exposed to pesticides had higher concentrations of cadmium and manganese. Higher concentrationsof vanadium, lead and arsenic were related to exposure to formaldehyde. Vanadium and lead werealso associated with exposure to chlorinated hydrocarbon solvents, and arsenic was related to exposure topolycyclic aromatic hydrocarbons (PAHs).Conclusions: Patients occupationally exposed to AHs, pesticides, chlorinated hydrocarbon solvents, formaldehyde,volatile sulphur compounds and PAHs had higher concentrations of several metals. These elementsmay account for some of the occupational risks previously reported for pancreatic cancer.
PB Elsevier
SN 0160-4120
YR 2019
FD 2019-03
LK http://hdl.handle.net/10272/16498
UL http://hdl.handle.net/10272/16498
LA eng
NO Camargo, J., Pumarega, J. A., Alguacil Ojeda, J. ... Sanz Gallén, P. (2019). Toenail concentrations of trace elements and occupational history in pancreatic cancer. Environment International, 127, 216–225. DOI: https://doi.org/10.1016/j.envint.2019.03.037
NO This work was partly supported by research grants from Instituto de Salud Carlos III, Ministry of Health, Government of Spain (FIS PI13/00020, FIS PI17/00088, and CIBER de Epidemiologia y Salud Publica - CIBERESP); the Hospital del Mar Medical Research Institute (IMIM), Barcelona; Fundacio La Marato de TV3 (20132910); and the Government of Catalonia (2009 SGR 1350, 2014 SGR 1012, 2017 SGR 439). The Dartmouth Trace Element Core was partially supported by NIH Grant Number P42 ES007373 from the National Institute of Environmental Health Sciences.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026