RT Journal Article
T1 Biocompatible and Thermoresistant Hydrogels Based on Collagen and Chitosan
A1 Sánchez Cid, Pablo
A1 Jiménez Rosado, Mercedes
A1 Rubio Valle, José Fernando
A1 Romero, Alberto
A1 Ostos, Francisco José
A1 El Idrissi Benhnia, Mohammed Rafii
A1 Pérez Puyana, Víctor
AB Hydrogels are considered good biomaterials for soft tissue regeneration. In this sense,collagen is the most used raw material to develop hydrogels, due to its high biocompatibility.However, its low mechanical resistance, thermal stability and pH instability have generated theneed to look for alternatives to its use. In this sense, the combination of collagen with another rawmaterial (i.e., polysaccharides) can improve the final properties of hydrogels. For this reason, themain objective of this work was the development of hydrogels based on collagen and chitosan. Themechanical, thermal and microstructural properties of the hydrogels formed with different ratios ofcollagen/chitosan (100/0, 75/25, 50/50, 25/75 and 0/100) were evaluated after being processed bytwo variants of a protocol consisting in two stages: a pH change towards pH 7 and a temperaturedrop towards 4 ◦C. The main results showed that depending on the protocol, the physicochemicaland microstructural properties of the hybrid hydrogels were similar to the unitary system dependingon the stage carried out in first place, obtaining FTIR peaks with similar intensity or a more porousstructure when chitosan was first gelled, instead of collagen. As a conclusion, the synergy betweencollagen and chitosan improved the properties of the hydrogels, showing good thermomechanicalproperties and cell viability to be used as potential biomaterials for Tissue Engineering
PB MDPI
SN 2073-4360 (electrónico)
YR 2022
FD 2022
LK http://hdl.handle.net/10272/20756
UL http://hdl.handle.net/10272/20756
LA eng
NO Sánchez-Cid, P., Jiménez-Rosado, M., Rubio-Valle, J. F., Romero, A., Ostos, F. J., Rafii-El-Idrissi Benhnia, M., & Perez-Puyana, V. (2022). Biocompatible and Thermoresistant Hydrogels Based on Collagen and Chitosan. In Polymers (Vol. 14, Issue 2, p. 272). MDPI AG. https://doi.org/10.3390/polym14020272
NO This research was funded by “FEDER/Ministerio de Ciencia e Innovación-Agencia Estatalde Investigación”, though the project RTI2018-097100-B-C21
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026