RT Journal Article
T1 Advanced interpenetrating polymer networks for innovative gastroretentive formulations targeting Helicobacter pylori gastric colonization
A1 Grosso, Roberto
A1 Benito Hernández, Elena
A1 Carbajo Gordillo, Ana I.
A1 Díaz Blanco, Manuel Jesús
A1 García Martín, María Gracia
A1 Paz Báñez, María Violante de
AB The escalating challenges of Helicobacter pylori-induced gastric complications, driven by rising antibiotic resistanceand persistent cancer risks, underscore the demand for innovative therapeutic strategies. This study addressesthis urgency through the development of tailored semi-interpenetrating polymer networks (semi-IPN)serving as gastroretentive matrices for amoxicillin (AMOX). They are biodegradable, absorb significant volume ofsimulated gastric fluid (swelling index > 360 %) and exhibit superporous microstructures, remarkablemucoadhesion, and buoyancy. The investigation includes assessment at pH 1.2 for comparative analysis withprior studies and, notably, at pH 5.0, reflecting the acidic environment in H. pylori-infected stomachs. The semi-IPN demonstrated gel-like structures, maintaining integrity throughout the 24-hour controlled release study, anddisintegrating upon completing their intended function. Evaluated in gastroretentive drug delivery system performance,AMOX release at pH 1.2 and pH 5.0 over 24 h (10 %-100 %) employed experimental design methodology,elucidating dominant release mechanisms. Their mucoadhesive, buoyant, three-dimensional scaffoldstability, and gastric biodegradability make them ideal for accommodating substantial AMOX quantities.Furthermore, exploring the inclusion of the potassium-competitive acid blocker (P-CAB) vonoprazan (VONO) inAMOX-loaded formulations shows promise for precise and effective drug delivery. This innovative approach hasthe potential to combat H. pylori infections, thereby preventing the gastric cancer induced by this pathogen.
PB Elsevier
SN 0928-0987
YR 2024
FD 2024-06
LK https://hdl.handle.net/10272/24304
UL https://hdl.handle.net/10272/24304
LA eng
NO Grosso, R., Benito, E., Carbajo-Gordillo, A. I., Díaz, M. J., García-Martín, M. G., & de-Paz, M.-V. (2024). Advanced interpenetrating polymer networks for innovative gastroretentive formulations targeting Helicobacter pylori gastric colonization. In European Journal of Pharmaceutical Sciences (Vol. 200, p. 106840). Elsevier BV. https://doi.org/10.1016/j.ejps.2024.106840
NO This research was funded by MICIU/AEI/10.13039/501100011033, grant number PID2020-115916GB-I00.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026