RT Journal Article
T1 Analysis of cardiovascular risk factors for the viability of cornea donors: a case–control study
A1 Montero Salinas, Alejandro
A1 Martínez Isasi, Santiago
A1 Fieira Costa, Eva
A1 Suanzes Hernández, Jorge
A1 Fernández García, Daniel
A1 Gómez Salgado, Juan
A1 Rendal Vázquez, Esther
AB Objective: The main objective of the study was to evaluate the influence of arterial hypertension, diabetes, dyslipidaemia, smoking, alcoholism and COPD (chronic obstructive pulmonary disease) on the viability of the extracted tissue as well as the donor.Design: Observational case-control study.Setting: Regional hospital in Northern Spain.Participants: 1517 corneas were registered.Interventions: Patients' medical history was reviewed after corneal donation and evaluation. Previous medical information (age, sex and cardiovascular risk factors (CVRFs)) and data related to the donor (type of donor), the corneal tissue and its evaluation, and the viability of the implant were collected.Results: A total of 1517 corneas were registered and 81.5% of the donors presented at least one CVRF. In relation to the viability of the donor, it was observed that having suffered from COPD reduced the viability of the donor (no COPD: 93.8% vs COPD: 88%; OR=0.49; 95% CI: 0.28 to 0.84) while alcohol consumption increased it (drinker or ex-drinker: 95.8% vs non-drinker: 92.5%; OR=1.84; 95% CI: 1.01 to 3.33). Regarding tissue viability, decreased viability was observed in the presence of COPD (no COPD: 72.5% vs COPD: 64; OR=0.67; 95% CI: 0.47 to 0.96) and diabetes mellitus (no diabetes: 72.9% vs diabetes: 67.2%; OR=0.76; 95% CI: 0.58 to 0.99). As regards the viability of the implant, a total of 1039 corneas (68.9%) were suitable, observing decreased viability when suffering from COPD (no COPD: 69.8% vs COPD: 60.7%; OR=0.67; 95% CI: 0.47 to 0.94) and increased when having an active smoking habit (no habit: 65.3% vs habit: 74.1%; OR=1.52; 95% CI: 1.21 to 1.91).Conclusions: Through this study, it can be concluded that in the absence of absolute exclusion criteria for donors, the assessment of how CVRF, alcoholism and COPD may affect the donor provides details about the quality of the tissue to be obtained.
PB BMJ Publishing Group
SN 2044-6055 (electrónico)
YR 2023
FD 2023-12
LK https://hdl.handle.net/10272/23941
UL https://hdl.handle.net/10272/23941
LA eng
NO Montero-Salinas, A., Martínez-Isasi, S., Fieira-Costa, E., Suanzes-Hernández, J., Fernández-García, D., Gómez-Salgado, J., & Rendal-Vazquez, E. (2023). Analysis of cardiovascular risk factors for the viability of cornea donors: a case–control study. In BMJ Open (Vol. 13, Issue 12, p. e077122). BMJ. https://doi.org/10.1136/bmjopen-2023-077122
NO Open Access funding provided thanks to the Fundación profesor Novoa Santos.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026