RT Journal Article T1 Effects of depression on patients suffering from ankylosing spondylitis: a comparative study A1 Cortés Rodríguez, Antonio A1 Alves Gomes, Lisa A1 Losa Iglesias, Marta Elena A1 Gómez Salgado, Juan A1 Becerro de Bengoa Vallejo, Ricardo A1 Saavedra García, Miguel Ángel A1 López López, Daniel A1 Jiménez Cebrián, Ana María AB BACKGROUND: Ankylosing spondylitis (AS) is a sustained inflammatory pathology that manifests as increasingrigidity and a continuous decline in spinal flexibility, leading to increasing lumbar pain during rest.OBJECTIVES: This study primarily aimed to evaluate depression assessments using the Beck DepressionInventory (BDI) and delineate depressive symptomatology in patients diagnosed with AS compared tothose without this condition.DESIGN AND SETTING: A comparative study was conducted in Medical Centers in Málaga, Spain.METHODS: A cohort of 102 participants, with a mean age of 46,80 ± 10,54 years, was divided into twosets: 51 individuals diagnosed with AS (cases) and another 51 without AS (controls), each harmonizedacross variables such as body mass index, age, and sex. Demographic variables were systematically gatheredfrom each participant, and the BDI responses were accurately recorded and subsequently analyzedfor comparison.RESULTS: Of the total sample, the sex distribution was 29.4% male and 70.6% female. BDI scores werehigher for the AS group (19.25 ± 15.5) than for the control group (5.33 ± 7). Notably, there were clear statisticaldifferences (P < 0.01) in the BDI categories, with elevated levels observed in participants with AS.CONCLUSIONS: Individuals with AS experienced higher levels of depression than those without AS. Furthermore,there were sex differences within the case group, with a higher percentage of women than menat any level of depression. Notably, there was a moderate inverse correlation between the number of yearssince diagnosis and depression level. PB Associação Paulista de Medicina SN 1516-3180 (electrónico) YR 2025 FD 2025 LK https://hdl.handle.net/10272/25509 UL https://hdl.handle.net/10272/25509 LA eng NO Cortés-Rodríguez, A., Alves-Gomes, L., Losa-Iglesias, M., Gómez-Salgado, J., Becerro-de-Bengoa-Vallejo, R., Saavedra-García, M. Á., López-López, D., & Jiménez-Cebrián, A. M. (2025). Effects of depression on patients suffering from ankylosing spondylitis: a comparative study. Sao Paulo Medical Journal, 143(2). https://doi.org/10.1590/1516-3180.2024.0177.r1.16102024 DS Repositorio Institucional de la Universidad de Huelva RD 31 may 2026