RT Journal Article T1 Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments A1 Giani, Micaela A1 Garbayo Nores, Inés A1 Vílchez Lobato, Carlos A1 Martínez Espinosa, María Rosa AB Haloarchaea are halophilic microorganisms belonging to the archaea domain that inhabitsalty environments (mainly soils and water) all over the world. Most of the genera included in thisgroup can produce carotenoids at significant concentrations (even wild-type strains). The majorcarotenoid produced by the cells is bacterioruberin (and its derivatives), which is only produced bythis kind of microbes and few bacteria, like Micrococcus roseus. Nevertheless, the understanding ofcarotenoid metabolism in haloarchaea, its regulation, and the roles of carotenoid derivatives in thisgroup of extreme microorganisms remains mostly unrevealed. Besides, potential biotechnologicaluses of haloarchaeal pigments are poorly explored. This work summarises what it has been describedso far about carotenoids from haloarchaea and their production at mid- and large-scale, paying specialattention to the most recent findings on the potential uses of haloarchaeal pigments in biomedicine. PB MDPI SN 1660-3397 YR 2019 FD 2019-09 LK http://hdl.handle.net/10272/16686 UL http://hdl.handle.net/10272/16686 LA eng NO Giani, M., Garbayo, I., Vílchez, C., & Martínez-Espinosa, R. M. (2019). Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments. Marine Drugs, 17(9), 524. DOI: https://doi.org/10.3390/md17090524 NO This work was partially funded by research grants from the MINECO Spain (CTM2013-43147-R;RTI2018-099860-B-I00) and University of Alicante (VIGROB-309). DS Repositorio Institucional de la Universidad de Huelva RD 31 may 2026