RT Journal Article
T1 Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up)
A1 Dierssen Sotos, Trinidad
A1 Gómez Acebo, Inés
A1 Gutiérrez Ruiz, Nuria
A1 Alguacil Ojeda, Juan
AB The aim of this study was to characterize the relationship between the intake of the majornutrients and prognosis in breast cancer. A cohort based on 1350 women with invasive (stage I-IV)breast cancer (BC) was followed up. Information about their dietary habits before diagnosis wascollected using a semi-quantitative Food Frequency Questionnaire. Participants without FFQ or withimplausible energy intake were excluded. The total amount consumed of each nutrient (Kcal/day)was divided into tertiles, considering as “high intakes” those above third tertile. The main effectstudied was overall survival. Cox regression was used to assess the association between death and nutrient intake. During a median follow-up of 6.5 years, 171 deaths were observed. None ofthe nutrients analysed was associated with mortality in the whole sample. However, in normalweightwomen (BMI 18.5–25 kg/m2) a high intake of carbohydrates ( 809 Kcal/day), specificallymonosaccharides ( 468 Kcal/day), worsened prognostic compared to lowest ( 352 Kcal/day).Hazard Ratios (HRs) for increasing tertiles of intake were HR:2.22 95% CI (1.04 to 4.72) and HR:2.5995% CI (1.04 to 6.48), respectively (p trend = 0.04)). Conversely, high intakes of polyunsaturated fats( 135 Kcal/day) improved global survival (HR: 0.39 95% CI (0.15 to 1.02) p-trend = 0.05) comparedto the lowest ( 92.8 kcal/day). In addition, a protective effect was found substituting 100 kcalof carbohydrates with 100 kcal of fats in normal-weight women (HR: 0.76 95% CI (0.59 to 0.98)).Likewise, in premenopausal women a high intake of fats ( 811 Kcal/day) showed a protective effect(HR:0.20 95% CI (0.04 to 0.98) p trend = 0.06). Finally, in Estrogen Receptors (ER) negative tumors,we found a protective effect of high intake of animal proteins ( 238 Kcal/day, HR: 0.24 95% CI(0.06 to 0.98). According to our results, menopausal status, BMI and ER status could play a role inthe relationship between diet and BC survival and must be taken into account when studying theinfluence of different nutrients.
PB MDPI
SN 1660-4601
YR 2020
FD 2020-12
LK http://hdl.handle.net/10272/19510
UL http://hdl.handle.net/10272/19510
LA eng
NO Dierssen Sotos, T., Gómez Acebo, I., Gutiérrez Ruiz, N. ... Alguacil Ojeda, J.(2020). Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up). International Journal of Environmental Research and Public Health, 18(1), 84. DOI: https://doi.org/10.3390/ijerph18010084
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026