RT Journal Article
T1 Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
A1 Domingo Relloso, Arce
A1 Grau Pérez, María
A1 Galán Chilet, Inmaculada
A1 Gómez Ariza, José Luis
AB Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stressin the general population.Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidativestress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA),and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain(Hortega Study).Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum(Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants.Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metaldistributions were 1.15 (95% confidence intervals [95% CI]: 1.03–1.27) for Mo, 1.17 (1.05–1.31) for Ba, 1.23(1.04–1.46) for Cr and 1.18 (1.00–1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13(1.03–1.24) for Zn and 1.12 (1.02–1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12(1.01–1.23) for Zn and 1.09 (0.99–1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most ofthe observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positivelyassociated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA.Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metalexposure levels relevant for the general population. The potential health consequences of environmental, includingnutritional, exposure to these metals warrants further investigation.
PB Elsevier
SN 0160-4120
YR 2019
FD 2019
LK http://hdl.handle.net/10272/16255
UL http://hdl.handle.net/10272/16255
LA eng
NO Domingo Relloso, A., Grau Pérez, M., Galán-Chilet, I., …Gómez Ariza, J. L.  Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study. Environment International, 123, 171–180. (2019). DOI: https://doi.org/10.1016/j.envint.2018.11.055
NO This work was supported by the Strategic Action for Research in Health Sciences [CP12/03080, PI10/0082, PI13/01848, PI07/0497 and PI11/00726]; GRUPOS 03/101, PROMETEO/2009/029 and 2005/027, AMP07/075 and ACOMP/2013/039 from the Valencia Government; GRS/279/A/08 from Castilla-Leon Government; European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission; Retics (PREDIMED RD06/0045/0006); CIBER Fisiopatología Obesidad y Nutrición (CIBERobn) [CIBER-02-08-2009, CB06/03 and CB12/03/30016] and CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM CB07/0/018). The Strategic Action for Research in Health sciences, Retics, CIBEROBN and CIBERDEM are initiatives from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER). The authors declare they have no actual or potential competing financial interests.
NO This work was supported by the Strategic Action for Research in Health Sciences [CP12/03080, PI10/0082, PI13/01848, PI07/0497 and PI11/00726]; GRUPOS 03/101, PROMETEO/2009/029 and 2005/027, AMP07/075 and ACOMP/2013/039 from the Valencia Government; GRS/279/A/08 from Castilla-Leon Government; European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission; Retics (PREDIMED RD06/0045/0006); CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn) [CIBER-02-08-2009, CB06/03 and CB12/03/30016] and CIBER de Diabetes y Enfermedades Metabolicas Relacionadas (CIBERDEM CB07/0/018). The Strategic Action for Research in Health sciences, Retics, CIBEROBN and CIBERDEM are initiatives from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER). The authors declare they have no actual or potential competing financial interests.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026