RT Journal Article
T1 MHC Class II Supertypes Affect Survival and Lifetime Reproductive Success in a Migratory Songbird
A1 Canal, David
A1 Roved, Jacob
A1 Lara Rodríguez, Antonio
A1 Camacho, Carlos
A1 Potti, Jaime
A1 Santoro, Simone
AB The major histocompatibility complex (MHC) plays a critical role in the immune response against pathogens. Its high polymorphismis thought to be mainly the consequence of host-pathogenco-evolution,but elucidating the mechanism(s) driving MHCevolution remains challenging for natural populations. We investigated the diversity of MHC class II genes in a wild populationof pied flycatchers Ficedula hypoleuca and tested its associations with two key components of individual fitness: lifetime reproductivesuccess and survival. Among 180 breeding adults in our study population, we found 182 unique MHC class II exon2 alleles. The alleles showed a strong signal of positive selection and grouped into nine functional supertypes based on physicochemicalproperties at the inferred antigen-bindingsites. Three supertypes were found in > 98% of the sampled individuals,indicating that they are nearly fixed in the population. We found no rare supertypes in the population, as all supertypes werepresent in > 70% of individuals. Three supertypes were related to different components of individual fitness: two were associatedwith lower offspring production over time, while the third was positively associated with survival. Overall, the substantial allelicand functional diversity and the relationship between specific supertypes and fitness are in accordance with the notion that balancingselection maintains MHC class II diversity in the study population, possibly with fluctuating selection as the underlyingmechanism. The absence of rare supertypes in the population suggests that the balancing selection is not driven by rare-alleleadvantage.
PB Wiley
SN 0962-1083
SN 1365-294X (electrónico)
YR 2024
FD 2024-11
LK https://hdl.handle.net/10272/24856
UL https://hdl.handle.net/10272/24856
LA eng
NO Canal, D., Roved, J., Lara, A., Camacho, C., Potti, J., & Santoro, S. (2024). MHC Class II Supertypes Affect Survival and Lifetime Reproductive Success in a Migratory Songbird. In Molecular Ecology (Vol. 33, Issue 22). Wiley. https://doi.org/10.1111/mec.17554
NO This work was supported by projects PAC05-006-2, CGL2006-07481/BOS from the Ministerio de Ciencia e Innovación, Spain. Most recently this work has been supported by the Comunidad Autónoma de Madrid (CAM), Spain (project: 2022-T1_AMB-24025 to DC) and the Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación, MCIN/AEI/10.13039/501100011033 (project: PID2022-141763NA-I00 to DC). D.C. received support from a CAM Talent Attraction grant associated with project 2022-T1_AMB-24025. C.C. was supported by the grant ref. RYC2021-033977-I funded by MCIN/AEI/10.13039/501100011033 and the European Union NextGenerationEU/PRTR. JR was funded by the Swedish Research Council grant 2020-06488.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026