RT Journal Article
T1 Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
A1 Arias Borrego, Ana
A1 Velasco, Inés
A1 Gómez Ariza, José Luis
A1 García Barrera, Tamara
AB Human breast milk (HBM) has a beneficial impact on health programming, growth and neurodevelopment of newborns. Increase in iodine intake is recommended for pregnant women in order to produce enough thyroid hormones to meet foetal requirements. In this work, a combined analytical multiplatform based on gas chromatography coupled to mass spectrometry and ultra-high performance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry has been applied in the first metabolomic study of HBM of iodinedeficient women. In addition, the elemental composition of HBM has been determined by inductively coupled plasma triple quadrupole mass spectrometry. Remarkably, 31 metabolites with important biological roles (e.g.glycerophospholipids for neurodevelopment) were seen to be altered in the HBM of iodine-deficient women. The main metabolic pathways altered include lipid metabolism, amino acid cycle, the tricarboxylic acid cycle and glycolysis. Additionally, the concentration of selenium, zinc and copper were seen to be significantly lower in HBM of iodine-deficient women.
PB Elsevier
SN 0308-8146
YR 2021
FD 2021
LK http://hdl.handle.net/10272/20398
UL http://hdl.handle.net/10272/20398
LA eng
NO Arias-Borrego, A., Velasco, I., Gómez-Ariza, J. L., & García-Barrera, T. (2022). Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk. In Food Chemistry (Vol. 371, p. 131329). Elsevier BV. https://doi.org/10.1016/j.foodchem.2021.131329
NO PG2018-096608-B-C21(Spanish Ministry of Science and innovation (MCIN). Generaci´on delConocimiento. MCIN/ AEI /10.13039/501100011033/ FEDER “Unamanera de hacer Europa”), UHU-1256905 and UHU-202009 from theFEDER Andalusian operative program (Regional Ministry of Economy,Knowledge, Business and University, Andalusia, Spain). Authors aregrateful to FEDER (European Community) for financial support, GrantsUNHU13-1E-1611 and UNHU15-CE-3140. Funding for open accesscharge: Universidad de Huelva / CBUA
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026