RT Journal Article
T1 Agreement in reporting of asthma by parents or offspring – the RHINESSA generation study
A1 Kuiper, Ingrid N.
A1 Svanes, Cecilie
A1 Benediktsdottir, Bryndis
A1 Sánchez Ramos, José Luis
AB Background: Self-report questionnaires are commonly used in epidemiology, but may be susceptible tomisclassification, especially if answers are given on behalf of others, e.g. children or parents. The aim was todetermine agreement and analyse predictors of disagreement in parents’ reports of offspring asthma, and inoffspring reports of parents’ asthma.Methods: In the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study, 6752offspring (age range 18–51 years) and their parents (age range 39–66 years) reported their own and each other’sasthma status. Agreement between asthma reports from offspring and parents was determined by calculatingsensitivity, specificity, positive and negative predictive value and Cohen’s kappa. The participants’ own answersregarding themselves were defined as the gold standard. To investigate predictors for disagreement logisticregression analyses were performed to obtain odds ratios (OR) with 95% confidence intervals (CI) for sex, smokingstatus, education, comorbidity and severity of asthma.Results: Agreement was good for parental report of offspring early onset asthma (< 10 years, Cohen’s kappa 0.72)and moderate for offspring later onset asthma (Cohen’s kappa 0.46). Specificity was 0.99 for both, and sensitivitywas 0.68 and 0.36, respectively. For offspring report of maternal and paternal asthma the agreement was good(Cohen’s kappa 0.69 and 0.68), specificity was 0.96 and 0.97, and sensitivity was 0.72 and 0.68, respectively. Thepositive predictive value (PPV) was lowest for offspring report of maternal asthma (0.75), and highest for parents’report of early onset asthma in the offspring (0.83). The negative predictive value (NPV) was high for all four groups(0.94–0.97). In multivariate analyses current smokers (OR = 1.46 [95% CI 1.05, 2.02]) and fathers (OR = 1.31 [95% CI 1.08, 1.59]) were more likely to report offspring asthma incorrectly. Offspring wheeze was associated with reportingparental asthma incorrectly (OR = 1.60 [95% CI 1.21, 2.11]), both under- and over reporting.Conclusions: Asthma reports across generations show moderate to good agreement, making information fromother generations a useful tool in the absence of direct reports.
PB BMC
SN 1471-2466
YR 2018
FD 2018-12
LK http://hdl.handle.net/10272/16112
UL http://hdl.handle.net/10272/16112
LA eng
NO Kuiper, I. N., Svanes, C., Benediktsdottir, B., Bertelsen, R. J., Bråbäck, L., Dharmage, S. C., … Johannessen, A. (2018). Agreement in reporting of asthma by parents or offspring – the RHINESSA generation study. BMC Pulmonary Medicine, 18(1). https://doi.org/10.1186/s12890-018-0687-4
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026