RT Journal Article
T1 Revision of Energy Metabolism Adaptations in High-Level Athletes: From Physical Performance Enhancement to Potential Therapeutic Targets in Mental Disorders
A1 Larrea, Ane
A1 Naji, Mariyem
A1 Gulak, Marina
A1 Torrecilla Sesma, María
A1 Barreda Gómez, Gabriel
AB High-level athletic performance requires the implementation of personalized strategies based on the analysis of metabolic pathways involved in energy production: phosphagen, glycolytic, and oxidative pathways. In this context, mitochondria play an essential role as the central regulator of energy production, being closely linked to these three pathways. Exercise boosts cellular respiration, which can also be optimized by nutritional interventions and targeted supplementation, promoting mitochondrial biogenesis, reducing oxidative stress and increasing ATP production. These metabolic adaptations improve athletic performance, accelerate recovery processes, and reduce the risk of injury, adapting to the physiological characteristics of each athlete. Moreover, some of these metabolic adaptations converge on specific targets whose expression or activity is also altered in mental disorders. Therefore, the aim of this review is to analyze mitochondrial adaptations induced by exercise and supplementation, evaluating their impact on the phosphagen, glycolytic, and oxidative metabolic pathways, as well as their relationship with optimizing performance and recovery in high-level athletes, with special attention to their potential application to mental health.
PB MDPI
SN 1467-3045 (electrónico)
YR 2026
FD 2026
LK https://hdl.handle.net/10272/28451
UL https://hdl.handle.net/10272/28451
LA eng
NO Larrea, A., Naji, M., Gulak, M., Torrecilla, M., & Barreda-Gómez, G. (2026). Revision of Energy Metabolism Adaptations in High-Level Athletes: From Physical Performance Enhancement to Potential Therapeutic Targets in Mental Disorders. Current Issues in Molecular Biology, 48(5), 498. https://doi.org/10.3390/cimb48050498
NO This work was supported by the Basque Government under grant PRE_2025_1_0426.
DS Repositorio Institucional de la Universidad de Huelva
RD 16 jul 2026