RT Journal Article
T1 Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes
A1 Lebrón, José Antonio
A1 López López, Manuel
A1 Moyá, María Luisa
A1 Deasy, Mary
A1 Muñoz Wic, Ana
A1 García Calderón, Clara B.
A1 Valle Rosado, Iván
A1 López Cornejo, Pilar
A1 Bernal, Eva
A1 Ostos, Francisco José
AB Gene therapy is a technique that is currently under expansion and development. Recentadvances in genetic medicine have paved the way for a broader range of therapies and laid thegroundwork for next-generation technologies. A terminally substituted difluorene-diester SchiffBase calix[4]arene has been studied in this work as possible nanovector to be used in gene therapy.Changes to luminescent behavior of the calixarene macrocycle are reported in the presence of ct-DNA.The calixarene macrocycle interacts with calf thymus DNA (ct-DNA), generating changes in itsconformation. Partial double-strand denaturation is induced at low concentrations of the calixarene,resulting in compaction of the ct-DNA. However, interaction between calixarene molecules themselves takes place at high calixarene concentrations, favoring the decompaction of the polynucleotide.Based on cytotoxicity studies, the calixarene macrocycle investigated has the potential to be used as ananovehicle and improve the therapeutic efficacy of pharmacological agents against tumors
PB MDPI
SN 2227-9040 (electrónico)
YR 2022
FD 2022-07
LK http://hdl.handle.net/10272/21098
UL http://hdl.handle.net/10272/21098
LA eng
NO Lebrón JA, López-López M, Moyá ML, Deasy M, Muñoz-Wic A, García-Calderón CB, Valle Rosado I, López-Cornejo P, Bernal E, Ostos FJ. Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes. Chemosensors. 2022; 10(7):281. https://doi.org/10.3390/chemosensors10070281
NO This work was financed by the Consejería de Conocimiento, Innovación yUniversidades de la Junta de Andalucía (FQM-206, FQM-274, and PY20-01234), the VI Plan PropioUniversidad de Sevilla (PP2019/00000748), RTI2018-100692-B-100; P18-RT-1271; PI18-0005-2018; VIPP AY.SUPLEM-2019; RYC-2015-18670 and the European Union (Feder Funds). F.J.O. thanks theUniversity of Seville for the grant VPPI-US (DOC_00963). J.A.L. also thanks the Fundación ONCEfunded by the Fondo Social Europeo
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026