RT Journal Article
T1 Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS-CoV-2 Positive Mothers
A1 Arias Borrego, Ana
A1 Soto Cruz, Francisco Javier
A1 Selma Royo, Marta
A1 Bäuerl, Christine
A1 García Verdevio, Elia
A1 Pérez-Cano, Francisco J.
A1 Lerin, Carles
A1 Velasco López, Inés
A1 Martínez-Costa, Cecilia
A1 Collado, Maria Carmen
A1 García Barrera, Tamara
AB Scope: Lack of information about the impact of maternal severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the elementaland metabolomic profile of human milk (HM).Methods and results: An observational study on HM from mothers withCOVID-19 is conducted including a prepandemic control group.Maternal–infant clinical records and symptomatology are recorded. Theabsolute quantification of elements and untargeted relative metabolomicprofiles are determined by inductively coupled plasma mass spectrometry andgas chromatography coupled to mass spectrometry, respectively. Associationsof HM SARS-CoV-2 antibodies with elemental and metabolomic profiles arestudied. COVID-19 has a significant impact on HM composition. COVID-19reduces the concentrations of Fe, Cu, Se, Ni, V, and Aluminium (Al) andincreases Zn compared to prepandemic control samples. A total of 18individual metabolites including amino acids, peptides, fatty acids andconjugates, purines and derivatives, alcohols, and polyols are significantlydifferent in HM from SARS-CoV-2 positive mothers. Aminoacyl-tRNAbiosynthesis, phenylalanine, tyrosine and tryptophan biosynthesis,phenylalanine, and linoleic acid pathways are significantly altered. Differencesare obtained depending on COVID-19 symptomatic and asymptomatic status.Conclusions: This study provides unique insights about the impact ofmaternal SARS-CoV-2 infection on the elemental and metabolomic profiles ofHM that warrants further research due the potential implications for infanthealth.
PB Wiley
SN 1613-4125
SN 1613-4133 (electrónico)
YR 2022
FD 2022-06-29
LK https://hdl.handle.net/10272/21403
UL https://hdl.handle.net/10272/21403
LA eng
NO Arias‐Borrego, A., Soto Cruz, F. J., Selma‐Royo, M., Bäuerl, C., García Verdevio, E., Pérez‐Cano, F. J., Lerin, C., Velasco López, I., Martínez‐Costa, C., Collado, M. C., & García‐Barrera, T. (2022). Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS‐CoV‐2 Positive Mothers. In Molecular Nutrition & Food Research (Vol. 66, Issue 16, p. 2200071). Wiley. https://doi.org/10.1002/mnfr.202200071
NO The authors thank all the families who were involved in the study during this difficult time and in the middle of the COVID-19 pandemic, as well as the collaborators of the MilkCORONA, which includes neonatologists, pediatricians, midwifes, nurses, research scientists, and computer/laboratory technicians. MCCispartoftheCSIC’sGlobalHealthPlatform (PTI Salud Global). This work was supported by the projects PG2018-096608-B-C21 (Spanish Ministry of Science and innovation (MCIN). Generación del Conocimiento. MCIN/ AEI /10.13039/501100011033/ FEDER “Una manera de hacer Europa”), UHU-1256905 and UHU-202009 from the FEDER Andalusian operative program (Ministry of Economic Transformation, Industry, Knowledge and Universities, Andalusia, Spain), and a research grant from Fundación La Marató-TV3 (MilkCORONA, ref 202106). FJSC thanks Junta de Andalucía and University of Huelva for a predoctoral contract (Ref. SNGJ5-TS-005, Garantía Juvenil). Funding for open access charge: Universidad de Huelva / CBUA. Theauthorsaregrateful to FEDER (European Community)forfinancialsupportthroughgrantsUNHU13-1E1611 and UNHU15-CE-3140. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of thedata;preparation,review,orapprovalofthemanuscript; and decision to submit the manuscript for publication.the projects PG2018-096608-B-C21(Spanish Ministry of Science and innovation (MCIN). Generación delConocimiento. MCIN/ AEI /10.13039/501100011033/ FEDER “Una manerade hacer Europa”), UHU-1256905 and UHU-202009 from the FEDERAndalusian operative program (Ministry of Economic Transformation, Industry,Knowledge and Universities, Andalusia, Spain), and a researchgrant from Fundación La Marató-TV3 (MilkCORONA, ref 202106). FJSCthanks Junta de Andalucía and University of Huelva for a predoctoralcontract (Ref. SNGJ5-TS-005, Garantía Juvenil). Funding for open accesscharge: Universidad de Huelva / CBUA. The authors are grateful to FEDER(European Community) for financial support through grants UNHU13-1E-1611 and UNHU15-CE-3140. The funding sources had no role in the designand conduct of the study; collection, management, analysis, and interpretationof the data; preparation, review, or approval of the manuscript;and decision to submit the manuscript for publication.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026