RT Journal Article
T1 Kinematic Analysis of Patients with Charcot–Marie–Tooth Disease Using OpenSim
A1 Martín Sosa, Ezequiel
A1 Mayo Núñez, Juana
A1 Ferrand Ferri, Patricia
A1 Zarco Periñán, María José
A1 Romero Sánchez, Francisco
A1 Ojeda Granja, Joaquín
K1 Charcot–Marie–Tooth; OpenSim; gait analysis; instability; ankle kinematics
AB This study proposes a methodology for conducting computational simulations of pathological gait. The literature shows a consensus that biomechanical models for gait analysis should be formulated as control problems. To achieve this, it is common prac-tice to guide the solution using kinematic or kinetic data to prevent temporal instabil-ity. The aim of this study is to implement a biomechanical model of the Charcot-–Marie-–Tooth disease in OpenSim software that enables more comprehensive simula-tions, which may in future involve the musculoskeletal system of patient and predic-tive studies. In this way, it will be possible to design specific active assistive devices tailored to each patient. Experimental gait data from six Charcot-–Marie-–Tooth pa-tients were used. The dataset comprises three-dimensional trajectories of reflective markers placed according to the Davis-Heel protocol. The acquired data allowed a pa-tient-specific adjustment of the biomechanical model. The inverse kinematic was solved, and the results were validated by comparing them with those obtained using the commercial BTS Bioengineering® software. The results show a strong alignment in ankle kinematics between the OpenSim model and the data generated by BTS Bioengi-neering®. Additionally, the kinematic results have been compared with normative curves, allowing the identification of potential areas for intervention using active as-sistive devices aimed at improving movement patterns of patients.
YR 2025
FD 2025-09
LK https://hdl.handle.net/10272/27304
UL https://hdl.handle.net/10272/27304
LA eng
NO Martín-Sosa, E.; Mayo, J.; Ferrand-Ferri, P.; Zarco-Periñán, M.J.; Romero-Sánchez, F.; Ojeda, J. Kinematic Analysis of Patients with Charcot–Marie–Tooth Disease Using OpenSim. Appl. Sci. 2025, 15, 10104. https://doi.org/10.3390/ app151810104
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026