RT Journal Article
T1 Evolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameters
A1 Herrera Quintana, Lourdes
A1 Vázquez-Lorente, Héctor
A1 Gamarra Morales, Yenifer
A1 Molina López, Jorge
A1 Planells, Elena
AB The inflammatory reaction and pathogenesis of COVID-19 may be modulated by circulating trace elements (Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn)) and Metallothioneins (MTs). Thus, the present study aimed to investigate their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 at the early Intensive Care Unit (ICU) phase. Critically ill patients (n = 86) were monitored from the first day of ICU admission until the third day of stay. Serum samples were used to assess mineral levels via Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and MT levels via differential pulse voltammetry. Levels of Cu and MTs were significantly decreased after 3 days (p < 0.05), increasing the prevalence of Cu-deficient values from 50% to 65.3% (p = 0.015). Fe and Zn were shown to have a predictive value for mortality and severity. The present study suggests trace element deficiency may be a risk factor during early ICU treatment of COVID-19, as it is related to different biochemical and clinical parameters, indicating a possible beneficial effect of restoring proper levels of these micronutrients.
PB MDPI
SN 2218-1989 (electrónico)
YR 2023
FD 2023-08
LK https://hdl.handle.net/10272/22526
UL https://hdl.handle.net/10272/22526
LA eng
NO Herrera-Quintana, L., Vázquez-Lorente, H., Gamarra-Morales, Y., Molina-López, J., & Planells, E. (2023). Evolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameters. In Metabolites (Vol. 13, Issue 8, p. 931). MDPI AG. https://doi.org/10.3390/metabo13080931
NO This publication was supported by the European Regional Development Fund (ERDF) “a way of making Europe”, funded via the Consejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía (REF. A-CTS-708-UGR20) and by Project FIS PI10/1993 from the Spanish Carlos III Health Institute. Lourdes Herrera-Quintana (REF. FPU18/03702) and Héctor Vázquez-Lorente (REF. FPU18/03655) were awarded a FPU fellowship from the Spanish Ministry of Education.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026