RT Journal Article
T1 Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release
A1 Iglesias González, María Nieves
A1 Galbis Fuster, Elsa
A1 Díaz Blanco, Manuel Jesús
A1 Lucas Rodríguez, Ricardo
A1 Benito Hernández, Elena
A1 Paz Báñez, María Violante de
AB In the present work, we demonstrate the preparation of chitosan-based composites asvehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed withpotential therapeutic effects on inflammatory bowel diseases (IBD), such as Crohn’s disease (CD)and ulcerative colitis, through the sustained colonic release of RES from long-lasting mucoadhesivedrug depots. The loading of RES into nanoparticles (NPs) was optimized regarding two independentvariables: RES/polymer ratio, and temperature. Twenty experiments were carried out and aBox–Behnken experimental design was used to evaluate the significance of these independentvariables related to encapsulation efficiency (EE). The enhanced RES EE values were achieved in24 h at 39 ◦C and at RES/polymer ratio of 0.75:1 w/w. Sizes and polydispersities of the optimizedNPs were studied by dynamic light scattering (DLS). Chitosan (CTS) dispersions containing theRES-loaded NPs were ionically gelled with tricarballylic acid to yield CTS-NPs composites. Macroandmicroscopic features (morphology and porosity studied by SEM and spreadability), thermalstability (studied by TGA), and release kinetics of the RES-loaded CTS-NPs were investigated. Releasepatterns in simulated colon conditions for 48 h displayed significant differences between the NPs(final cumulative drug release: 79–81%), and the CTS-NPs composites (29–34%).
PB MDPI
SN 1661-6596
YR 2019
FD 2019-01
LK http://hdl.handle.net/10272/18226
UL http://hdl.handle.net/10272/18226
LA eng
NO Iglesias González, M. N., Galbis Fuster, E., Díaz Blanco, M. J., Lucas Rodríguez, R., Benito Hernández, E., Paz Bañez, M. V. de (2019). Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release. International Journal of Molecular Sciences, 20(2), 398. DOI: https://doi.org/10.3390/ijms20020398
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026