RT Journal Article
T1 Occupational heat exposure and prostate cancer risk: A pooled analysis of case-control studies
A1 Hinchliffe, Alice
A1 Alguacil Ojeda, Juan
A1 Bijoux, Wendy
A1 Kogevinas, Manolis
A1 Menegaux, Florence
A1 Parent, Marie-Elise
A1 Pérez Gómez, Beatriz
A1 Uuksulainen, Sanni
A1 Turner, Michelle C.
AB Background: Heat exposures occur in many occupations. Heat has been linked to key carcinogenic processes,however, evidence for associations with cancer risk is sparse. We examined potential associations betweenoccupational heat exposure and prostate cancer risk in a multi-country study.Methods: We analysed a large, pooled dataset of 3142 histologically confirmed prostate cancer cases and 3512frequency-matched controls from three countries: Canada, France, and Spain. Three exposure indices: everexposure, lifetime cumulative exposure and duration of exposure, were developed using the Finnish Job-Exposure Matrix, FINJEM, applied to the lifetime occupational history of participants. We estimated odds ratios(ORs) and 95% confidence intervals (CIs), using conditional logistic regression models stratified by 5-yearage groups and study, adjusting for potential confounders. Potential interactions with exposure to other occupationalagents were also explored.Results: Overall, we found no association for ever occupational heat exposure (OR 0.97; 95% CI 0.87, 1.09), norin the highest categories of lifetime cumulative exposure (OR 1.04; 95% CI 0.89, 1.23) or duration (OR 1.03; 95%CI 0.88, 1.22). When using only the Spanish case-control study and a Spanish Job Exposure Matrix (JEM), someweakly elevated ORs were observed.Conclusions: Findings from this study provide no clear evidence for an association between occupational heatexposure and prostate cancer risk.
PB Elsevier
SN 0013-9351
YR 2023
FD 2023
LK https://hdl.handle.net/10272/22307
UL https://hdl.handle.net/10272/22307
LA eng
NO Hinchliffe, A., Alguacil, J., Bijoux, W., Kogevinas, M., Menegaux, F., Parent, M.-E., Pérez Gomez, B., Uuksulainen, S., & Turner, M. C. (2023). Occupational heat exposure and prostate cancer risk: A pooled analysis of case-control studies. In Environmental Research (Vol. 216, p. 114592). Elsevier BV. https://doi.org/10.1016/j.envres.2022.114592
NO The study was partially funded by the "Accion Transversal del Cancer", approved by the Spanish Ministry Council on October 11, 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI12/00265), the Fundación Marqués de Valdecilla(API 10/09), the Junta de Castilla y León (LE22A10–2), the Consejería de Salud of the Junta de Andalucía (2009-S0143), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa  (2010ACUP 00310), the Regional Government of the Basque Country, the Consejería de Sanidad de la Región de Murcia, the European Commission grants FOOD-CT-2006–036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, the CatalanGovernment DURSI grant 2014SGR647, the Fundación Caja de Ahorros de Asturias and by the University of Oviedo. MCT is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and co-funded by the European Social Fund. We acknowledge support from the Spanish Ministry ofScience and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX 2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. PROtEuS was supported financially through grants from the Canadian Cancer Society (grants no. 13149, 19,500, 19,864 and 19,865), the Cancer ResearchSociety, the Fonds de Recherche du Québec-Santé (FRQS), FRQSR Réseau de recherche en santé environnementale, the Ministère du Développement  économique, de l’Innovation et de l’Exportation du Québec, and the Canadian Institutes of Health Research (grant no. 159704). The EPICAP Study was funded by Ligue nationale contre le cancer, Ligue contre le cancer du Val-de-Marne, Fondation de France, Agence nationale de securite sanitaire de l’alimentation, de  l’environnement et du travail (ANSES).
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026