RT Journal Article
T1 Selenium Levels and Antioxidant Activity in Critically Ill Patients with Systemic Inflammatory Response Syndrome
A1 Herrera Quintana, Lourdes
A1 Vázquez Lorente, Héctor
A1 Molina López, Jorge
A1 Gamarra Morales, Yenifer
A1 Planells, Elena
AB The Selenium (Se) status could be an important modifiable factor in critically ill patientoutcomes due to the important role of this mineral in several functions. Although there are manyclinical trials with Se interventions in the literature, the evidence is not sufficient to establish acommon criterion regarding the Se status. Background and aims: An analysis was made of theevolution of selenium (Se) and antioxidant status in critically ill patients with Systemic InflammatoryResponse Syndrome (SIRS) over 7 days of staying in the Intensive Care Unit (ICU). Methods: Aprospective analytical study was carried out on 65 critically ill patients aged 31–77 years. A healthycontrol group of 56 volunteers from the same region was recruited to allow comparisons withreference normal values. The selenium levels in both the plasma and erythrocytes were analyzedby Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Glutathione Peroxidase (GPx) andSuperoxide Dismutase (SOD) activity and the Total Antioxidant Capacity (TAC) were measuredusing kinetic colorimetric methods. Results: Low erythrocyte and plasma Se levels were found atICU admission in comparison with the healthy reference group (p < 0.001), and the levels furtherdecreased after one week (p < 0.001). Smaller changes in the plasma Se levels were associated withgreater changes in the Sequential Organ Failure Assessment (SOFA) score (p < 0.05). The GPx activityin the critically ill was lower than in the control group (p < 0.05), with an inverse correlation to theseverity scores at the baseline (p < 0.05) and reaching normal values after one week (p < 0.05). SODactivity was directly correlated to TAC (p = 0.03), with both parameters exhibiting a direct correlationto albumin (p < 0.05) after 7 days of ICU stay. Conclusions: A deficient Se status was observed at ICUadmission and worsened further over follow-up regardless of the evolution of the patient severityand the antioxidant parameters. Adequate Se support from the start of admission could preserve andcontribute to improve the Se-related outcomes and critical patient recovery during longer periods inthe ICU
PB MDPI
SN 2218-1989 (electrónico)
YR 2022
FD 2022
LK http://hdl.handle.net/10272/20793
UL http://hdl.handle.net/10272/20793
LA eng
NO Herrera-Quintana L, Vázquez-Lorente H, Molina-López J, Gamarra-Morales Y, Planells E. Selenium Levels and Antioxidant Activity in Critically Ill Patients with Systemic Inflammatory Response Syndrome. Metabolites. 2022; 12(4):274. https://doi.org/10.3390/metabo12040274
NO This study received external funding from FIS projects of the Carlos III Health Institute[REF. PI10/1993] and FEDER Andalucía (REF. A-CTS-708-UGR20). L.H.-Q. (FPU2018/03655) andH.V.-L. (FPU2018/03702) are under an FPU fellowships from the Spanish Ministry of Education.
DS Repositorio Institucional de la Universidad de Huelva
RD 14 jul 2026