RT Journal Article
T1 The metallome of lung cancer and its potential use as biomarker
A1 Callejón Leblic, María Belén
A1 Arias Borrego, Ana
A1 Pereira Vega, Antonio
A1 Gómez Ariza, José Luis
A1 García Barrera, Tamara
AB Carcinogenesis is a very complex process in which metals have been found to be criticallyinvolved. In this sense, a disturbed redox status and metal dyshomeostasis take place during the onsetand progression of cancer, and it is well-known that trace elements participate in the activation orinhibition of enzymatic reactions and metalloproteins, in which they usually participate as cofactors.Until now, the role of metals in cancer have been studied as an effect, establishing that cancer onsetand progression affects the disturbance of the natural chemical form of the essential elements in themetabolism. However, it has also been studied as a cause, giving insights related to the high exposureof metals giving a place to the carcinogenic process. On the other hand, the chemical species of themetal or metallobiomolecule is very important, since it finally affects the biological activity or thetoxicological potential of the element and their mobility across different biological compartments.Moreover, the importance of metal homeostasis and metals interactions in biology has also beendemonstrated, and the ratios between some elements were found to be different in cancer patients;however, the interplay of elements is rarely reported. This review focuses on the critical role ofmetals in lung cancer, which is one of the most insidious forms of cancer, with special attention tothe analytical approaches and pitfalls to extract metals and their species from tissues and biofluids,determining the ratios of metals, obtaining classification profiles, and finally defining the metallomeof lung cancer.
PB MDPI
SN 1661-6596
SN 1422-0067 (electrónico)
YR 2019
FD 2019
LK http://hdl.handle.net/10272/16036
UL http://hdl.handle.net/10272/16036
LA eng
NO Callejón-Leblic, B., Arias-Borrego, A., Pereira-Vega, A., Gómez-Ariza, J., & García-Barrera, T. (2019). The Metallome of Lung Cancer and its Potential Use as Biomarker. International Journal of Molecular Sciences, 20(3), 778. https://doi.org/10.3390/ijms20030778
NO This research was funded by the projects CTM2015-67902-C-1-P from the Spanish Ministry of Economyand Competitiveness, and P12-FQM-0442 from the Regional Ministry of Economy, Innovation, Science andEmployment (Andalusian Government, Spain). Projects Neumosur (8/2012 and 9/2015) and SEPAR (124/2012and 091/2016). Belén Callejón Leblic thanks the Ministry of Education, Culture and Sport for a predoctoralscholarship. Finally, authors are grateful to FEDER (European Community) for financial support, grants numberUNHU13-1E-1611 and UNHU15-CE-3140.
DS Repositorio Institucional de la Universidad de Huelva
RD 14 jul 2026