RT Journal Article
T1 Photovermellogens: Minimalistic Pyridinium-Based Acylhydrazones with Photoswitchable Basicity for Operation in Aqueous Media
A1 Vila García, Alejandro
A1 Blandón Cumbreras, Francisco G.
A1 Pauls, Mike
A1 Díaz Abellás, Mauro
A1 Blanco Gómez, Arturo
A1 Peinador Veira, Carlos
A1 Remón Ruiz, Patricia
A1 Bannwarth, Christoph
A1 Pischel, Uwe
A1 García Romero, Marcos Daniel
AB Examples of a new class of synthetically straightforward and hydrolytically inert photoswitchable acylhydrazones, named photovermellogens, have been successfully developed and comprehensively studied using state-of-the-art spectroscopic and computational techniques. These compounds present photoswitchable basicity, with irradiation promoting E→Z photoisomerizations, which result in the generation of a less acidic species. The observed ΔpKa values > 1.5 within the biologically relevant window underscore the potential of photovermellogens as versatile platforms for light-triggered pH control.
PB American Chemical Society
SN 0022-3263
SN 1520-6904 (electrónico)
YR 2026
FD 2026
LK https://hdl.handle.net/10272/28497
UL https://hdl.handle.net/10272/28497
LA eng
NO Vila, A., Blandón-Cumbreras, F. G., Pauls, M., Díaz-Abellás, M., Blanco-Gómez, A., Peinador, C., Remón, P., Bannwarth, C., Pischel, U., & García, M. D. (2026). Photovermellogens: Minimalistic Pyridinium-Based Acylhydrazones with Photoswitchable Basicity for Operation in Aqueous Media. The Journal of Organic Chemistry. https://doi.org/10.1021/acs.joc.5c02962
NO The authors are grateful for the funding received from the MCIN/AEI/10.13039/501100011033 and ERDF A way of making Europe (PID2022-137361NB-I00 for C.P./M.D.G., PID2020-119992GB-I00 and PID2023-152556NB-I00 for U.P. and predoctoral contract PRE2023-001520 for F.G.B.- C.), and the Consellería de Cultura, Educación e Universidade da Xunta de Galicia (ED431C 2022/39). M.D.-A. thanks Ministerio de Universidades for his predoctoral fellowship (FPU21/06302). A.B.-G. thanks the Consellería de Cultura, Educación e Universidade da Xunta de Galicia for his postdoctoral fellowship (ED481D-2024-020). M.D.G. thanks CESGA (Xunta de Galicia) for computational time. C.B. acknowledges funding from the Federal Ministry of Education and Research (BMBF) and the Ministry of Culture and Science of the German State of North Rhine-Westphalia (MKW) under the Excellence Strategy of the Federal Government and the Länder (RWTH JPI Fellowship), as well as funding from the MKW via the NRW Rückkehrprogramm.
DS Repositorio Institucional de la Universidad de Huelva
RD 14 jul 2026