RT Journal Article
T1 Epidemiology of non-steroidal antiinflammatory drugs consumption in Spain. The MCC-Spain study
A1 Gómez Acebo, Inés
A1 Dierssen Sotos, Trinidad
A1 Pérez Gómez, Beatriz
A1 Capelo Álvarez, Rocío
AB Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinalbleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we includedemographic factors, health-related behaviours and cardiovascular disease history.Methods: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practicelists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption,demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition,participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factorsassociated with ever and current NSAID consumption were identified by logistic regression.Results: Women consumed more non-aspirin NSAIDs (38.8% [36.7–41.0]) than men (22.3 [20.5–24.2]), but menconsumed more aspirin (11.7% [10.3–13.2]) than women (5.2% [4.3–6.3]). Consumption of non-aspirin NSAIDs decreasewith age from 44.2% (39.4–49.1) in younger than 45 to 21.1% (18.3–24.2) in older than 75, but the age-pattern foraspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%)than in women (5.2%); its consumption increased with age from 1.7% (< 45 years old) to 12.4% (≥75 years old). Aspirinwas strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reachingodds ratios of 15.2 (7.4–31.2) in women with acute coronary syndrome, 13.3 (6.2–28.3) in women with strokes and 11.1(7.8–15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed asmuch non-aspirin NSAID as participants without such conditions.Conclusions: Non-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirinand non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher theaspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did notdecrease their non-aspirin NSAIDs usage.
PB BMC
SN 1471-2458
YR 2018
FD 2018-09
LK http://hdl.handle.net/10272/16830
UL http://hdl.handle.net/10272/16830
LA eng
NO Gómez Acebo, I., Dierssen Sotos, T.,  Pérez Gómez, B., ...  Capelo Álvarez, R. (2019) Epidemiology of non-steroidal antiinflammatory drugs consumption in Spain. The MCC-Spain study.  BMC Public Health (2018) 18:1134.
NO This work was partially funded by the "Accion Transversal del Cancer", approved on the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-Leon, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundacion Marques de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economia y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Tematica de Investigacion del Cancer (RTICC) del ISCIII (RD12/0036/0036)); The Junta de Castilla y Leon [LE22A10-2]; The Consejeria de Salud of the Junta de Andalucia [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejeria de Sanidad de la Region de Murcia; The European Commission [grants FOOD-CT-2006-036224-HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundacion Caja de Ahorros de Asturias; and the University of Oviedo. The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026