RT Journal Article
T1 Breathlessness across generations: results from the RHINESSA generation study
A1 Ekström, Magnus
A1 Sánchez Ramos, José Luis
A1 Svanes, Cecilie
AB Background Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations.Methods We analysed the association between breathlessness in parents and their offspring in the Respiratory Health in Northern Europe, Spain and Australia generation study. Data on parents and offspring aged ≥18 years across 10 study centres in seven countries included demographics, self-reported breathlessness, asthma, depression, smoking, physical activity level, measured Body Mass Index and spirometry. Data were analysed using multivariable logistic regression accounting for clustering within centres and between siblings.Results A total of 1720 parents (mean age at assessment 36 years, 55% mothers) and 2476 offspring (mean 30 years, 55% daughters) were included. Breathlessness was reported by 809 (32.7%) parents and 363 (14.7%) offspring. Factors independently associated with breathlessness in parents and offspring included obesity, current smoking, asthma, depression, lower lung function and female sex. After adjusting for potential confounders, parents with breathlessness were more likely to have offspring with breathlessness, adjusted OR 1.8 (95% CI 1.1 to 2.9). The association was not modified by sex of the parent or offspring.Conclusion Parents with breathlessness were more likely to have children who developed breathlessness, after adjusting for asthma, lung function, obesity, smoking, depression and female sex in both generations. The hereditary components of breathlessness need to be further explored.
PB BMJ Publishing Group
SN 0040-6376
SN 1468-3296 (electrónico)
YR 2021
FD 2021
LK http://hdl.handle.net/10272/20916
UL http://hdl.handle.net/10272/20916
LA eng
NO Ekström, M., Johannessen, A., Abramson, M. J., Benediktsdottir, B., Franklin, K., Gislason, T., Gómez Real, F., Holm, M., Janson, C., Jogi, R., Lowe, A., Malinovschi, A., Martínez-Moratalla, J., Oudin, A., Sánchez-Ramos, J. L., Schlünssen, V., & Svanes, C. (2021). Breathlessness across generations: results from the RHINESSA generation study. In Thorax (Vol. 77, Issue 2, pp. 172–177). BMJ. https://doi.org/10.1136/thoraxjnl-2021-217271
NO ME was supported by unrestricted grants from the Swedish Societyfor Medical Research and the Swedish Research Council (Dnr: 2019-02081).Coordination and establishment of the Respiratory Health in Northern Europe, Spainand Australia (RHINESSA) study has received funding from the Research Councilof Norway (grant numbers 274767, 214123, 228174, 230827 and 273838), ERCStG project BRuSH (#804199), the European Union’s Horizon 2020 research andinnovation programme (grant agreement number 633212) (the ALEC Study WP2),the Bergen Medical Research Foundation and the Western Norwegian RegionalHealth Authorities (grant numbers 912011, 911892 and 911631). Study centreshave further received local funding from the following: Bergen: the above grants,World University Network (REF and Sustainability grants), Norwegian LabourInspection, the Norwegian Asthma and Allergy Association. Albacete and Huelva:Sociedad Española de Patología Respiratoria (SEPAR) Fondo de InvestigaciónSanitaria (FIS PS09). Göteborg, Umeå and Uppsala: the Swedish Heart and LungFoundation, the Swedish Asthma and Allergy Association. Reykjavik: IcelandUniversity. Melbourne: NHMRC Project Grant ID1128450, Melbourne University.Tartu: the Estonian Research Council (grant number PUT562). Århus: The DanishWood Foundation (grant number 444508795), the Danish Working EnvironmentAuthority (grant number 20150067134), Aarhus University (PhD scholarship). TheRHINE study has received funding from Danish Lung Association, Estonian ScienceFoundation, Icelandic Research Council, Norwegian Research Council, NorwegianAsthma and Allergy Association, Swedish Asthma and Allergy Association, SwedishHeart and Lung Foundation and Vårdal Foundation for Health Care Science andAllergy Research. The coordination of the ECRHS has been supported by theEuropean Union’s Horizon 2020 research and innovation programme (grantagreement number 633212) (the ALEC study), the Medical Research Council (ECRHSIII) and the European Commission FP5 and FP7 (ECRHS I and II). ECRHS IV is beingplanned and the 10 RHINESSA study centres are funded by ERC StG project BRuSH(#804199) and by the European Union’s Horizon 2020 research and innovationprogramme (grant agreement number 874703) (the EPHOR project). Further fundingagencies for ECRHS are reported elsewhere.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026