RT Journal Article
T1 Factors related to mortality of patients with COVID-19 who are admitted to the ICU Prognostic mortality factors of COVID-19 patients
A1 Álvarez Macías, Alejandro
A1 Úbeda Iglesias, Alejandro
A1 Macías Seda, Juana
A1 Gómez Salgado, Juan
AB During the severe acute respiratory syndrome coronavirus 2 pandemic, hospital resources, particularly critical care units, wereoverburdened and this had a significant impact on both the therapies and the prognosis of these patients. This study aimed toidentify factors and therapies that may improve prognosis and other factors associated with increased mortality. A secondaryobjective was to evaluate the impact that obesity had on these patients. An observational study was conducted on 482 patientsaged 18 years or older who were diagnosed with SARS-CoV-2 pneumonia and admitted to the Intensive Care Units of 3 nationalhospitals registered in the CIBERESUCICOVID database between September 2020 and March 2021. After identifying the sampleprofile, risk factors were analyzed, the predictive model was constructed, and crude odd ratios were calculated for each factor.Additionally, logistic regression was used to build the multivariate model adjusting for potential confounders. The final modelincluded only the variables selected using the Backward method. A sample of 335 men (69.5%) and 145 women (30.08%) aged61.94 ± 12.75 years with a body mass index (BMI) of 28.05 (25.7; 31.2) was obtained. A total of 113 patients received noninvasivemechanical ventilation. The most common comorbidities were: high blood pressure (51.04%), obesity (28%), diabetes mellitus(23.44%), other metabolic diseases (21.16%), chronic heart failure (18.05%), chronic obstructive pulmonary disease (11.62%),and chronic kidney disease (10.16%). In-hospital, 3-month and 6-month post-discharge mortality in patients with BMI > 30(n = 135) versus BMI ≤ 30 (n = 347) was significantly different (P = .06). Noninvasive mechanical ventilation failed in 42.4% ofpatients with BMI > 30 compared to 55% of patients with BMI ≤ 30. This study identified the factors associated with failureof mechanical ventilation. The most common comorbidities were congestive heart failure, high blood pressure, chronic kidneydisease, severe liver disease, diabetes mellitus, and solid organ transplantation. In terms of ventilatory support, patients whoreceived high-flow nasal oxygen therapy on admission had lower mortality rates. The use of renal replacement therapy was alsosignificantly associated with higher mortality.
PB Wolters Kluwer Health
SN 0025-7974
SN 1536-5964 (electrónico)
YR 2024
FD 2024-04
LK https://hdl.handle.net/10272/23980
UL https://hdl.handle.net/10272/23980
LA eng
NO Álvarez-Macías, A., Úbeda-Iglesias, A., Macías-Seda, J., & Gómez-Salgado, J. (2024). Factors related to mortality of patients with COVID-19 who are admitted to the ICU: Prognostic mortality factors of COVID-19 patients. In Medicine (Vol. 103, Issue 21, p. e38266). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1097/md.0000000000038266
DS Repositorio Institucional de la Universidad de Huelva
RD 15 jul 2026