@article{10272/23487,
year = {2024},
month = {4},
url = {https://hdl.handle.net/10272/23487},
abstract = {Cognitive impairment (CI) is a complication of chronic kidney disease (CKD) that is
frequently observed among patients. The aim of this study was to evaluate the potential crosstalk
between changes in cognitive function and the levels of Klotho in the brain cortex in an experimental
model of CKD. To induce renal damage, Wistar rats received a diet containing 0.25% adenine for six
weeks, while the control group was fed a standard diet. The animals underwent different tests for
the assessment of cognitive function. At sacrifice, changes in the parameters of mineral metabolism
and the expression of Klotho in the kidney and frontal cortex were evaluated. The animals with
CKD exhibited impaired behavior in the cognitive tests in comparison with the rats with normal
renal function. At sacrifice, CKD-associated mineral disorder was confirmed by the presence of
the expected disturbances in the plasma phosphorus, PTH, and both intact and c-terminal FGF23,
along with a reduced abundance of renal Klotho. Interestingly, a marked and significant decrease
in Klotho was observed in the cerebral cortex of the animals with renal dysfunction. In sum, the
loss in cerebral Klotho observed in experimental CKD may contribute to the cognitive dysfunction
frequently observed among patients. Although further studies are required, Klotho might have
a relevant role in the development of CKD-associated CI and represent a potential target in the
management of this complication.},
organization = {This work was funded by the Carlos III Health Institute (CP21/00048 and PI23/01018) and co-funded by the European Union.
M.E.R.-O. is supported by the Miguel Servet Program from Carlos III Health Institute (ISCIII) (CP21/00048). M.V.P.-R.M. is a recipient of a Juan Rodes Contract from ISCIII (2021-2025). J.R.M.-C. is a senior researcher supported by the Nicolas Monardes Programme, Consejeria de Salud y Consumo-Servicio Andaluz de Salud (Junta de Andalucia).},
publisher = {MDPI},
title = {Cognitive Impairment Related to Chronic Kidney Disease Is Associated with a Decreased Abundance of Membrane-Bound Klotho in the Cerebral Cortex},
doi = {10.3390/ijms25084194},
author = {Rodríguez Ortiz, M. Encarnación and Canalejo Raya, Antonio and Muñoz Castañeda, Juan R.},
}