RT Journal Article
T1 Cognitive Impairment Related to Chronic Kidney Disease Is Associated with a Decreased Abundance of Membrane-Bound Klotho in the Cerebral Cortex
A1 Rodríguez Ortiz, M. Encarnación
A1 Canalejo Raya, Antonio
A1 Muñoz Castañeda, Juan R.
AB Cognitive impairment (CI) is a complication of chronic kidney disease (CKD) that isfrequently observed among patients. The aim of this study was to evaluate the potential crosstalkbetween changes in cognitive function and the levels of Klotho in the brain cortex in an experimentalmodel of CKD. To induce renal damage, Wistar rats received a diet containing 0.25% adenine for sixweeks, while the control group was fed a standard diet. The animals underwent different tests forthe assessment of cognitive function. At sacrifice, changes in the parameters of mineral metabolismand the expression of Klotho in the kidney and frontal cortex were evaluated. The animals withCKD exhibited impaired behavior in the cognitive tests in comparison with the rats with normalrenal function. At sacrifice, CKD-associated mineral disorder was confirmed by the presence ofthe expected disturbances in the plasma phosphorus, PTH, and both intact and c-terminal FGF23,along with a reduced abundance of renal Klotho. Interestingly, a marked and significant decreasein Klotho was observed in the cerebral cortex of the animals with renal dysfunction. In sum, theloss in cerebral Klotho observed in experimental CKD may contribute to the cognitive dysfunctionfrequently observed among patients. Although further studies are required, Klotho might havea relevant role in the development of CKD-associated CI and represent a potential target in themanagement of this complication.
PB MDPI
SN 1422-0067 (electrónico)
YR 2024
FD 2024-04
LK https://hdl.handle.net/10272/23487
UL https://hdl.handle.net/10272/23487
LA eng
NO Rodríguez-Ortiz, M. E., Jurado-Montoya, D., Valdés-Díaz, K., García-Sáez, R. M., Torralbo, A. I., Obrero, T., Vidal-Jiménez, V., Jiménez, M. J., Carmona, A., Guerrero, F., Pendón-Ruiz de Mier, M. V., Rodelo-Haad, C., Canalejo, A., Rodríguez, M., Soriano-Cabrera, S., & Muñoz-Castañeda, J. R. (2024). Cognitive Impairment Related to Chronic Kidney Disease Is Associated with a Decreased Abundance of Membrane-Bound Klotho in the Cerebral Cortex. In International Journal of Molecular Sciences (Vol. 25, Issue 8, p. 4194). MDPI AG. https://doi.org/10.3390/ijms25084194
NO This work was funded by the Carlos III Health Institute (CP21/00048 and PI23/01018) and co-funded by the European Union.M.E.R.-O. is supported by the Miguel Servet Program from Carlos III Health Institute (ISCIII) (CP21/00048). M.V.P.-R.M. is a recipient of a Juan Rodes Contract from ISCIII (2021-2025). J.R.M.-C. is a senior researcher supported by the Nicolas Monardes Programme, Consejeria de Salud y Consumo-Servicio Andaluz de Salud (Junta de Andalucia).
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026