RT Journal Article
T1 The role of pristine carbon nanotubes as nanocarriers of 7,8-dihydroxyflavone
A1 Espíndola, Cecilia
A1 Gómez-Méndez, Ana
A1 Moyá, María Luisa
A1 López-Vallejo, Fabián
A1 Bernal, Eva
A1 Lebrón, José Antonio
A1 Martín, Victoria Isabel
A1 Ostos, Francisco José
A1 López Cornejo, Pilar
A1 López López, Manuel
AB Flavonoids are secondary plant metabolites with a wide range of pharmacological effects. Among others, their antioxidant, anti-inflammatory and vasoprotective actions are noteworthy. However, the low bioavailability of flavonoids limits their direct clinical use. Nanoencapsulation of flavonoids is an effective tool to improve their biopharmaceutical characteristics, as the drug is protected inside the nanocarrier and specifically released into the therapeutic target. Bearing this in mind, pristine single- and multi-walled carbon nanotubes have been studied in this work as nanocarriers of 7,8-dihydroxyflavone, 7,8-DHF. Flavone encapsulation is optimized according to the influence of pH, the type of CNTs and their concentration on the association process. The equilibrium binding constants of 7,8-DHF to the CNTs are determined by measuring the variation observed in the flavone absorbance when the concentration of carbon nanotubes increases. CNTs/flavone complexes are characterized by particle size distribution and Z-potential measurements, as well as Transmission Electron Microscopy. The antioxidant capacity of free 7,8-DHF and the CNTs/7,8-DHF complexes are estimated by using the DPPH⋅, 2,2-diphenyl-1-picrylhydrazyl radical scavenging method. The results show that the encapsulation of the flavone in the CNTs results in a preservation of its pharmacological properties and provides stability to the encapsulated drug.
PB Elsevier
SN 1773-2247
YR 2024
FD 2024-08
LK https://hdl.handle.net/10272/25145
UL https://hdl.handle.net/10272/25145
LA eng
NO Espíndola, C., Gómez-Méndez, A., Moyá, M. L., López-Vallejo, F., Bernal, E., Lebrón, J. A., Martín, V. I., Ostos, F. J., López-Cornejo, P., & López-López, M. (2024). The role of pristine carbon nanotubes as nanocarriers of 7,8-dihydroxyflavone. In Journal of Drug Delivery Science and Technology (Vol. 100, p. 106068). Elsevier BV. https://doi.org/10.1016/j.jddst.2024.106068
NO This research was funded by the Consejería de Educaci´ on y Ciencia de la Junta de Andalucía (FQM-206 and FQM-274), the European Union (Feder Funds), and the Project PAIDI P20-01234.Funding for open access charge: Universidad de Huelva / CBUA
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026