RT Journal Article
T1 Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
A1 Gutiérrez González, Enrique
A1 Castelló, Adela
A1 Fernández Navarro, Pablo
A1 Alguacil Ojeda, Juan
AB Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplasticcells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studiesis a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study,considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incidentcases and 1228 population-based controls were included for this study. Dietary zinc was assessedusing a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotidepolymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increasedrisk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidenceinterval (CI):1.00–1.95). This association was mainly observed in low grade PC (Gleason = 6 RRRtertile 3vs1: 1.76; 95% CI:1.18–2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95%CI:1.00–1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89–2.53). In conclusion,a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men withhigher genetic susceptibility might also have a higher risk of PC associated with this nutrient intake.
PB MDPI
SN 2072-6643
YR 2018
FD 2018-12
LK http://hdl.handle.net/10272/16399
UL http://hdl.handle.net/10272/16399
LA eng
NO Gutiérrez González, E., Castelló, A., Fernández Navarro, P.... Alguacil Ojeda, J. (2018). Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study. Nutrients, 11(1), 18. DOI: https://doi.org/10.3390/nu11010018
NO The study was supported by the "Accion Transversal del Cancer", approved on the Spanish Ministry Council on the 11 October 2007, by the Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), by the Instituto de Salud Carlos III grants, co-funded by FEDER funds -a way to build Europe-PI08/1770, PI09/0773, PI12/00715, PI09/1903, PI09/2078; PI09/1662; PI11/01403; PI12/00150; PI12/00488; PI15/00914; PI17CIII_00034; by the Fundacion Marques de Valdecilla grant API 10/09, by the Consejeria de Salud of the Junta de Andalucia grant 2009-S0143, by the Conselleria de Sanitat of the Generalitat Valenciana grant AP061/10, by the Regional Government of the Basque Country, by the Fundacion Caja de Ahorros de Asturias, by the University of Oviedo and by the Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporacion grant IJCI-2014-20900.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026