RT Journal Article
T1 Extracts from Microalgae and Archaea from the Andalusian Coast: A Potential Source of Antiproliferative, Antioxidant, and Preventive Compounds
A1 Luque Uceda, Cristina
A1 Gómez-Villegas, Patricia
A1 Vigara Fernández, Javier
A1 León Bañares, Rosa María
A1 Melguizo Alonso, Consolación
AB Marine and extreme environments harbor a huge diversity of microorganisms able toproduce new bioactive metabolites with beneficial health effects. In this study, ethanol, aqueous,methanol, and acetone extracts and protein hydrolysates were obtained from five different microalgaespecies and two haloarchaea. An in vitro study of cytotoxicity, migration, angiogenic effect, antioxidantcapacity, and modulation of detoxifying enzyme expression was carried out using resistant(HCT-15) and non-resistant (T84) colon cancer tumor lines. Our results showed that the aqueousextract of the microalga Chlorella sorokiniana induced the greatest cytotoxic effect in both cell lines,while the ethanolic extracts of the archaea Haloarcula hispanica and Halobacterium salinarum caused thegreatest inhibition on the migratory capacity. Meanwhile, the protein hydrolyzate and the aqueousextract of the microalga Chlorella sorokiniana significantly protected cells against hydrogen peroxidedamage. Moreover, the aqueous extracts of Haloarcula hispanica and Halobacterium salinarum resultedin inducing the greatest increase in the activity of the detoxifying enzymes enzyme quinone oxidoreductaseand glutathione S-transferase. These preliminary results suggest that aqueous extracts ofsome microalgae and haloarchaea may be promising candidates for an adjuvant therapy againstcolorectal cancer. However, additional research is required to identify the active principles andelucidate the mechanisms of action involved.
PB MDPI
SN 2077-1312 (electrónico)
YR 2024
FD 2024-06
LK https://hdl.handle.net/10272/24085
UL https://hdl.handle.net/10272/24085
LA eng
NO Luque, C., Perazzoli, G., Gómez-Villegas, P., Vigara, J., Martínez, R., García-Beltrán, A., Porres, J. M., Prados, J., León, R., & Melguizo, C. (2024). Extracts from Microalgae and Archaea from the Andalusian Coast: A Potential Source of Antiproliferative, Antioxidant, and Preventive Compounds. In Journal of Marine Science and Engineering (Vol. 12, Issue 6, p. 996). MDPI AG. https://doi.org/10.3390/jmse12060996
NO This research was funded by the Campus de Excelencia Internacional Global del Mar (CEI·Mar 2022) (Project CEI-JD-19.1 and CEI-JD-19.2) and Agencia Estatal de Investigación (grant PID2022-140995OB-C21 by MICIU/AEI/10.13039/501100011033 and ERDF/EU).
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026