RT Journal Article
T1 Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance
T2 Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance
A1 Iglesias Blanco, Nieves
A1 Galbis Fuster, Elsa
A1 Valencia Barragán, Concepción
A1 Díaz Blanco, Manuel Jesús
A1 Lacroix, Bertrand
A1 Paz Báñez, María Violante de
AB This study investigates the impact of dual ionic and covalent cross-links (ion-XrL and cov-XrL) on the properties of chitosan-based (CTS) hydrogels as eco-friendly drug delivery systems (DDS) for the model drug diclofenac sodium(DCNa). Citric acid and a diiodo-trehalose derivative (ITrh)were the chosen ionic and covalent cross-linker, respectively. The novel hydrogels completely disintegrated within 96 h by means of a hydrolysis process mediated by the enzyme trehalase. As far as the authors are aware, this is the first time that a trehalose derivative has been used as a covalent cross-linker in the formation of biodegradable hydrogels. The impact of CTS concentration and degree of cov-XrL on rheological parameterswere examined by means of an experimentalmodel design and marked differences were found between the materials. Hydrogels with maximum elastic properties were achieved at high CTS concentrations and high degrees of cov-XrL. DCNa-loaded formulations displayed well-controlled drug-release profiles strongly dependent on formulation composition (from 17% to 40% in 72 h). Surprisingly, higher degrees of covalent cross-linking led to a boost in drug release. The formulations presented herein provides a simple and straightforward pathway to design fully biodegradable, tailor-made controlled drug delivery systems with improved rheological properties.
PB Elsevier
SN 0141-8130
SN 1879-0003 (electrónico)
YR 2020
FD 2020-12
LK https://hdl.handle.net/10272/27244
UL https://hdl.handle.net/10272/27244
LA eng
NO Iglesias Blanco, N., Galbis Fuster, E., Valencia, C., Díaz Blanco, M.J., Lacroix, B. y Paz Báñez, M.V.d. (2020). Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance. International Journal of Biological Macromolecules, 165, 2205-2218. https://doi.org/10.1016/j.ijbiomac.2020.10.006
NO -
NO Ministerio de Ciencia, Innovación y Universidades (MICIU) of Spain (Grant MAT2016-77345-C3-2-P)
NO Junta de Andalucía (Grant P12-FPM-1553)
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026