RT Journal Article
T1 Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
A1 Gómez Acebo, Inés
A1 Alguacil Ojeda, Juan
A1 Llorca, Javier
AB Purpose The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after newtreatments were generalised and to ascertain the current efect that tumour characteristics such as grade, stage or subtypehave on survival as well as the new AJCC-pathological prognostic score.Methods The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases.Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanishprovinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-upusing Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigateprognosis factors.Results Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled therisk of dying, while N3 nodal involvement and presence of metastasis had a huge efect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94,7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively.Conclusion Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish womenwith breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved withrisk indices that increased rapidly as the pathological prognosis score increased
PB Springer
SN 0167-6806
SN 1573-7217 (electrónico)
YR 2020
FD 2020
LK http://hdl.handle.net/10272/20831
UL http://hdl.handle.net/10272/20831
LA eng
NO Gómez-Acebo, I., Dierssen-Sotos, T., Palazuelos-Calderón, C., Pérez-Gómez, B., Amiano, P., Guevara, M., Molina, A. J., Domingo, L., Fernández-Ortiz, M., Moreno, V., Alguacil, J., Fernández-Tardón, G., Ibáñez, J., Marcos-Gragera, R., Diaz-Santos, M., Alonso, M. H., Alonso-Molero, J., Castaño-Vinyals, G., Palomo, A. G., … Llorca, J. (2020). Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study. In Breast Cancer Research and Treatment (Vol. 181, Issue 3, pp. 667–678). Springer Science and Business Media LLC. https://doi.org/10.1007/s10549-020-05600-x
NO Biological samples were stored at the biobanks supportedby Instituto de Salud Carlos III- FEDER: Parc de Salut MAR Biobank(MARBiobanc) (RD09/0076/00036), ‘Biobanco La Fe’ (RD 090076/00021) and FISABIO Biobank (RD09 0076/00058), as well asat the Public Health Laboratory of Gipuzkoa, the Basque Biobank, theICOBIOBANC (sponsored by the Catalan Institute of Oncology), theIUOPA Biobank of the University of Oviedo and the ISCIII Biobank.SNP genotyping services were provided by the Spanish ‘CentroNacional de Genotipado’ (CEGEN-ISCIII). We thank all the subjectswho participated in the study and all MCC-Spain collaborators. Thiswork was supported by the ‘Acción Transversal del Cancer’, approvedby the Spanish Ministry Council on the 11th October 2007, by theInstituto de Salud Carlos III, co-founded by FEDER funds – ‘a way tobuild Europe’ (grants PI08/1770, PI08/0533, PI08/1359, PI09/00773,PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488,PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219,PI14/00613 and PI15/00069). Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09); the Junta de Castillay León (grant LE22A10-2); the Consejería de Salud of the Junta deAndalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (grant AP 061/10); the Recercaixa (grant 2010ACUP00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commissiongrants FOOD-CT-2006–036224-HIWATE; the Spanish AssociationAgainst Cancer (AECC) Scientifc Foundation; the Catalan Government DURSI (grant 2014SGR647); the Fundación Caja de Ahorros deAsturias; the University of Oviedo; Societat Catalana de Digestologia;and COST action BM1206 Eucolongene.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026