RT Journal Article T1 The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain A1 Palomar Cros, Anna A1 Espinosa, Ana A1 Straif, Kurt A1 Pérez Gómez, Beatriz A1 Papantoniou, Kyriaki A1 Gómez Acebo, Inés A1 Molina Barceló, Ana A1 Olmedo Requena, Rocío A1 Alguacil Ojeda, Juan A1 Fernández Tardón, Guillermo A1 Casabonne, Delphine A1 Aragonés, Nuria A1 Castaño Vinyals, Gemma A1 Pollán, Marina A1 Romaguera, Dora A1 Kogevinas, Manolis AB Nighttime fasting has been inconclusively associated with a reduced risk of cancer. Thepurpose of this study was to investigate this association in relation to prostate cancer risk. We examined data from 607 prostate cancer cases and 848 population controls who had never worked innight shift work from the Spanish multicase-control (MCC) study, 2008–2013. Through an interview,we collected circadian information on meal timing at mid-age. We estimated odds ratios (OR) and95% confidence intervals (CI) with unconditional logistic regression. After controlling for time ofbreakfast, fasting for more than 11 h overnight (the median duration among controls) was associatedwith a reduced risk of prostate cancer compared to those fasting for 11 h or less (OR = 0.77, 95%0.54–1.07). Combining a long nighttime fasting and an early breakfast was associated with a lowerrisk of prostate cancer compared to a short nighttime fasting and a late breakfast (OR = 0.54, 95% CI0.27–1.04). This study suggests that a prolonged nighttime fasting duration and an early breakfastmay be associated with a lower risk of prostate cancer. Findings should be interpreted cautiouslyand add to growing evidence on the importance of chrononutrition in relation to cancer risk PB MDPI SN 2072-6643 (electrónico) YR 2021 FD 2021 LK http://hdl.handle.net/10272/20290 UL http://hdl.handle.net/10272/20290 LA eng NO Palomar-Cros, A., Espinosa, A., Straif, K., Pérez-Gómez, B., Papantoniou, K., Gómez-Acebo, I., Molina-Barceló, A., Olmedo-Requena, R., Alguacil, J., Fernández-Tardón, G., Casabonne, D., Aragonés, N., Castaño-Vinyals, G., Pollán, M., Romaguera, D., & Kogevinas, M. (2021). The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain. In Nutrients (Vol. 13, Issue 8, p. 2662). MDPI AG. https://doi.org/10.3390/nu13082662 NO : Instituto de Salud Carlos III FIS PI11/01889. Anna Palomar-Cros is supported by a MINECO(Ministry of Economy in Spain) fellowship. We acknowledge support from the Spanish State ResearchAgency and Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through theCERCA Program DS Repositorio Institucional de la Universidad de Huelva RD 1 jun 2026