RT Journal Article T1 Simple and Efficient Green Extraction of Steviol Glycosides from Stevia rebaudiana Leaves A1 López Carbón, Verónica A1 Sayago Gómez, Ana A1 González Domínguez, Raúl A1 Fernández Recamales, María Ángeles AB The food industry has currently shown great interest in alternative sweeteners to sugarswith the aim of producing healthier products. In light of this, steviol glycosides are naturallow-caloric sweeteners present in Stevia rebaudiana, which have additionally been described asbioactive components with potential therapeutic properties. In this work, a green method for theextraction of steviol glycosides from stevia leaves was optimized by applying a factorial screeningdesign of five variables (time, temperature, agitation, grinding, and sample–solvent ratio) and thesubsequent response surface design of Box-Behnken. The optimized extraction method allows for therecovery of stevia sweeteners in a simple and e cient manner by using tap water as the extractant,without the application of an auxiliary energy source to reduce costs, thus representing an interestingstrategy for their industrial-scale production. PB MDPI SN 2304-8158 YR 2019 FD 2019-09 LK http://hdl.handle.net/10272/16959 UL http://hdl.handle.net/10272/16959 LA eng NO López Carbón, V., Sayago Gómez, A., González Domínguez, R., Fernández Recamales, Á. (2019). Simple and Efficient Green Extraction of Steviol Glycosides from Stevia rebaudiana Leaves. Foods, 8(9), 402. DOI: https://doi.org/10.3390/foods8090402 DS Repositorio Institucional de la Universidad de Huelva RD 31 may 2026