RT Journal Article
T1 Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth
A1 Santos, Cristina
A1 García Fuentes, Eduardo
A1 Callejón Leblic, María Belén
A1 García Barrera, Tamara
A1 Gómez Ariza, José Luis
A1 Rayman, Margaret P.
A1 Velasco, Inés
AB The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother–baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC. Additional measurements of serum SeP concentration and of serum GPx-3 enzyme activity were carried out using ELISA. Total Se concentration was significantly higher in maternal serum than in cord serum (68·9 (sd 15·2) and 56·1 (sd 14·6) µg/l, respectively; P<0·01). There were significant correlations between selenoprotein and SeAlb concentrations in mothers and newborns, although they also showed significant differences in GPx-3 (11·2 (sd 3·7) v. 10·5 (sd 3·5) µg/l; P<0·01), SeP (42·5 (sd 9·5) v. 28·1 (sd 7·7) µg/l; P<0·01) and SeAlb (11·6 (sd 3·6) v. 14·1 (sd 4·3) µg/l; P<0·01) concentrations in maternal and cord sera, respectively. Serum GPx-3 activity and concentration were positively correlated in mothers (r 0·33; P=0·038) but not in newborns. GPx-3 activity in cord serum was significantly correlated with gestational age (r 0·44; P=0·009). SeAlb concentration was significantly higher in babies, whereas SeP and GPx-3 concentrations were significantly higher in mothers. The differences cannot be explained by simple diffusion; specific transfer mechanisms are probably involved. GPx-3 concentrations in mothers, at delivery, are related to maternal Se status, whereas the GPx-3 activity in cord serum depends on gestational age.
PB Cambridge University Press
SN 0007-1145
SN 1475-2662 (electrónico)
YR 2017
FD 2017
LK http://hdl.handle.net/10272/14679
UL http://hdl.handle.net/10272/14679
LA eng
NO Santos, C., García Fuentes, E., Callejón Leblic, M.B., García Barrera, T., Gómez Ariza, J.L., Rayman, M.P., Velasco, I.: "Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth". British Journal of Nutrition. Vol. 117, n. 9, págs. 1304-1311, (2017). DOI: 10.1017/S0007114517001155
NO This study was undertaken with the aid of a grant from the Consejeria de Salud of the Junta de Andalucia, Spain (PI-0373/2012) and by projects CTM2012-38720-C03-01 from the Spanish Ministry of Economy and Competitiveness (MINECO) and P12-FQM-0442 from the Regional Ministry of Economy, Innovation, Science and Employment (Andalusian Government, Spain). B. C.-L. thanks the Spanish Ministry of Education, Culture and Sport for a doctoral grant.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026