RT Journal Article
T1 Regioselective Formation of 2,5-Disubstituted Oxazoles Via Copper(I)-Catalyzed Cycloaddition of Acyl Azides and 1-Alkynes
A1 Cano Rico, Israel
A1 Álvarez, Eleuterio
A1 Nicasio Jaramillo, María Carmen
A1 Pérez Romero, Pedro José
AB The reaction of 1-alkynes with acylazides in the presence of [Tpm*,BrCu(NCMe)]BF4 (Tpm*,Br = tris(3,5-dimethyl-4-bromopyrazolyl)methane) as the catalyst provides 2,5-oxazoles in moderate to high yields. This is a novel transformation of CuAAC type, that constitutes a significant variation of the commonly observed [3+2] cycloaddition reaction to yield 1,2,3-triazoles
PB American Chemical Society
SN 0002-7863
SN 1520-5126 (electrónico)
YR 2011
FD 2011
LK http://hdl.handle.net/10272/11553
UL http://hdl.handle.net/10272/11553
LA eng
NO Cano. I.. Álvarez, E., Nicasio Jaramillo, M.C., Pérez Romero, P.J.: "Regioselective Formation of 2,5-Disubstituted Oxazoles Via Copper(I)-Catalyzed Cycloaddition of Acyl Azides and 1-Alkynes". Journal of the American Chemical Society. Vol 133, págs. 191-193, (2011). DOI: 10.1021/ja109732s
NO This work is dedicated to Prof. Jose Barluenga on the occasion of his retirement. This research was financially supported by MEC (Proyecto CTQ2008-00042/BQU, Consolider Ingenio 2010, Grant CSD2006-003) and the Junta de Andalucia (Proyecto P07-FQM-02745). I.C. thanks MEC for a research fellowship. We gratefully acknowledge Prof. Antonio Echavarren for helpful discussions. Dr. Ana Caballero and Dr. Tomas R. Belderrain are thanked for assistance with GC MS and NMR studies.MEC (Proyecto CTQ2008-00042/BQU, Consolider Ingenio 2010, Grant No. CSD2006-003) and the Junta de Andalucía (Proyecto P07-FQM-02745).
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026